Research Abstract:
Our work uses functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) to study human brain organization and function in health and disease.
The research can be divided into two general categories: studies of normal human brain function and studies of the biological origins of functional brain imaging signals obtained with MRI and PET. We use fMRI to determine systems within the normal human brain concerned with specific cognitive and emotional functions. We are also studying patients with psychiatric diseases such as depression and anxiety to determine the system responsible for the disease and the response of these systems to treatment. We use both PET and MRI to relate changes in blood flow and brain metabolism to underlying changes in cellular activity associated with brain function.
Selected Publications:
Fox MD, Snyder AZ, Zacks JM, Raichle ME. Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain resonses. Nature Neurosci 2006 9:23-25.
Raichle ME. The Brain's Dark Energy. Science 2006 314:1249-1250.
Raichle ME, Mintun MA. Brain work and brain imaging. Annual Review of Neurosci 2006 29:449-476.
Vincent, JL, Snyder, AZ, Fox, MD, et al. Coherent spontaneous activity identifies a hippocampal-parietal memory network. J Neurophysiology 2006 96:3517-3531.
Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. PNAS 2005 102:9673-9678.
Last Updated: 01/16/2007 |