Pathobiology of Human Disease States Course Information

Welcome to the Homepage for the Markey Pathway course at Washington University School of Medicine.  The course meets every Tuesday and Thursday during the fall semester.  Markey students should register for 2.0 units of L41 Bio 5191. 

**Please note that acceptance into the Markey Pathway is required to attend the course**
Information about the course & how to apply can be found at:
http://dbbs.wustl.edu/curstudents/SpecialEmphasisPathways/Pages/Markey.aspx

Course Location:  FLTC 213 - Farrell Learning & Teaching Center, Room 213
Date(s):  08/29/2017 - 11/21/2017 Tuesdays & Thursdays ONLY
Time:  1:30 PM - 3:00 PM, Unless Noted on the Schedule

Class attendance is required. Please check the schedule for class time changes or alternate locations.

Mandatory Clinical Mentorship Orientation – Thursday, December 14​th at 1:30pm

Fall 2017 Class Topics:
Section 1:  Immunotherapy
Section 2:  Alzheimer's
Section 3:  Hearing Loss 

Section I - Immunotherapy

Section Leader:  Todd A. Fehniger, M.D., Ph.D., Associate Professor of Medicine, Divistion of Oncology, Section:  Bone Marrow Transplant

​Date

​Location

​Speaker

Topic​​

Aug 29

FLTC 213
(1:30-3:00pm)

Todd Fehniger, MD PhD
Associate Professor of Medicine, Division of Oncology, Section: Bone Ma​rrow Transplant​

Intro to the Markey Pathway & Course

Intro to Immunology

Concepts (Immunology Bootcamp)

Adoptive Natural Killer Cell Therapy

​Aug 31

FLTC 213
(1:30-3:00pm)

Rizwan Romee, MD
Assistant Professor, Oncology
BMT & Leukemia
Clinical Director, Haploidentical Transplant Program

Hematopoietic stem cell transplantation

Patient Visit

​Sept 5

FLTC 213

 

TIME CHANGE:
2:00-3:30pm

John DiPersio, MD PhD
Virginia E. and Samuel J Golman Endowed Professorship of Medicine, Pathology & Immunology

Professor, Pediatrics & Pathology
Chief, Division of Oncology

Deputy Director, Siteman Cancer Center

Multispecific immune targeting agents for cancer therapy

Patient Visit

Sept 7

FLTC 213
(1:30-3:00pm)

Gavin Dunn, MD PhD
Assistant Professor, Neurological Surgery, Pathology & Immunology
Center for Human Immunology & Immunotherapy Programs

Personalizing T cell immunotherapy for brain cancer and checkpoint blockade

Challenges of personalized medicine clinical trials

Sept 12

 

 

 

 

LOCATION & TIME CHANGE:

Lobby, CAM

1:30-3:30pm

FIELD TRIP

 

BJH Apheresis Center, Cell Processing Lab, SCC Biological Therapy Core, and Clinical BMT unit

Follow the NK and Stem Cells!

(Note: 2 hours!)

​Sept 14

FLTC 213
(1:30-3:00pm)

David DeNardo, PhD
Associate Professor, Medicine
Division of Oncology
I
CCE Institute


Andrea Wang-Gillam, MD PhD
Associate Professor, Medicine
Division of Oncology
Section: Medical Oncology

Tumor microenvironment impact on the immune response

Sept 19

FLTC 213
(1:30-3:00pm)

Amanda Cashen, MD
Associate Professor, Medicine
Division of Oncology
Section: Bone Marrow Transplant

Chimeric antigen receptor modified T cells for cancer immunotherapy

Patient Visit

Sept 21

FLTC 213

TIME CHANGE:
1:00-2:30pm

ALL

Wrap up discussion & lunch

Section II - Alzheimer's

Section Leaders: Joy Snider, MD, PhD, Associate Professor, Neurology & Nupur Ghoshal, MD, PhD, Assistant Professor, Neurology​

​Date

​Location

​Speaker

Topic

Sept 26

FLTC 213
(1:30-3:00pm)

John C. Morris, MD
Harvey A. & Dorismae Hacker
Friedman Professor of Neurology
Professor, Pathology & Immunology
Director, Center for Aging
Director, Memory & Aging Project
Director, Alzheimer’s Disease Research Center

Introduction to Alzheimer’s Disease

Patient Visit

​Sept 28

FLTC 213
(1:30-3:00pm)

John Cirrito, PhD
Associate Professor, Neurology

Anne Fagan, PhD
Professor, Neurology

Abeta and tau metabolism/fluid biomarkers in Alzheimer’s Disease

​Oct 3

FLTC 213

(1:30-3:00pm)

Beau Ances, MD PhD MSc
Associate Professor, Neurology

Imaging in dementia

Oct 5

FLTC 213
(1:30-3:00pm)

Gregory Day, MD MSc FRCPC
Instructor, Neurology
Clinical Director, The Anti-NMDA Receptor Encephalitis Foundation

Autoimmune Encephalopathies

Patient Visit

Oct 10

FLTC 213
(1:30-3:00pm)

Timothy Miller, MD PhD
David Clayson Professor of Neurology

RNA targeted therapeutic strategies for dementia

Oct 11

NOTE TIME CHANGE:
FLTC 213
(1:00-2:30pm)

Nupur Ghoshal, MD PhD
Assistant Professor, Neurology
Non AD de​mentias

Oct 12

CLASS RESCHEDULED

CLASS RESCHEDULED TO 10/11

CLASS RESCHEDULED TO 10/11

Oct 17 ​NO CLASS ​FALL BREAK​
NO CLASS

Oct 19

FLTC 213
(1:30-3:00pm)

Brendan Lucey, MD
Assistant Professor, Neurology

Sleep science and dementias

Oct 24

FLTC 213
(1:30-3:00pm)

ALL

Wrap up discussion & lunch

Section III - Hearing Loss

Section Leaders: Keiko Hirose, MD, Professor, Otolaryngology, Division Director, Pediatric Otolaryngology & Mark Rutherford, PhD, Assistant Professor, Otolaryngology

​Date
​Location
​Speaker
Topic​
Oct 26
FLTC 213
(1:30-3:00pm)
Craig Buchman, MD
Lindburg Professor & Chair, Otolaryngology
Hearing loss and Cochlear Implantation
+ Patient Visit
​Oct 31
FLTC 213
(1:30-3:00pm)
Lavinia Sheets, PhD
Assistant Professor, Otolaryngology
 
 
Genetics and Hearing Loss
​Nov 2
FLTC 213
(1:30-3:00pm)
Keiko Hirose, MD
Professor, Otolaryngology
Division Director, Pediatric Otolaryngology  
Cochlear Inflammation
Nov 7
FLTC 213
(1:30-3:00pm)
Jeffrey Lichtenhan, PhD
Assistant Professor, Otolaryngology
 
Mark Rutherford, PhD
Assistant Professor, Otolaryngology
Otoacoustic Emission Probes of Cochlear Mechanics / Cochlear Neuropathy and Synaptopathy
Nov 9
FLTC 213
(1:30-3:00pm)
Mark Rutherford, PhD
Assistant Professor, Otolaryngology

Mark Warchol, PhD
Professor, Otolaryngology
Professor, Anatomy & Neurobiology

Lavinia Sheets, PhD
Assistant Professor, Otolaryngology

Jeffrey Lichtenhan, PhD
Assistant Professor, Otolaryngology
Inner Ear Anatomy Demonstration /
Field Trip: Surgical Labs
Nov 14
FLTC 213
(1:30-3:00pm)
Richard Chole, MD PhD
Professor, Otolaryngology
Biofilms and Bacterial Resistance
Nov 16
FLTC 213
(1:30-3:00pm)
MichaelAnne Gratton, PhD
Professor, Otolaryngology
 
Mark Warchol, PhD
Professor, Otolaryngology
Professor, Anatomy & Neurobiology
Presbycusis / Sensory Regeneration
 
Nov 21
FLTC 213
(1:30-3:00pm)
ALL
Wrap up Discussion & Lunch
Nov 28
FLTC 213
(2:00-3:30pm)
Tim McBride, PhD, MS
Professor, Brown School
Health Policy Analyst & Health Economist
Co-Director, Center for Health Economics & Policy
Bonus Talk! Economics of Healthcare
Dec 14
FLTC 213
(1:30-2:00pm)
Kelle Moley, MD
James P. Crane Professor in Obstetrics & Gynecology
Vice Chair & Director, Basic Science Research in OB/Gyn
Mandatory Clinical Mentorship Orientation

Past Course Modules

Year
Modules
1992
1. Sickle Cell Anemia
2. Malaria​
3. Diabetes
1993
1. Cystic Fibrosis
2. Coronary Artery Disease
3. AIDS
1994
1. Sickle Cell Anemia
2. Emphysema
3. Acute Leukemia 
1995
1. Multiple Endocrine Neoplasia
2. Undue Susceptibility to Infection
3. Alzheimer’s Disease
1996
1. Sickle Cell Disease
2. Multiple Sclerosis
3. Epstein Barr Virus
1997
1. Osteoporosis
2. Thrombophilia
3. Congenital Malformations
1998
1. Sickle Cell Disease
2. Hepatitis C
3. Chronic Myelogenous Leukemia
1999
1. Rheumatoid Arthritis
2. AIDS
3. Prostate Cancer
2000
1. Sickle Cell Disease
2. Epstein Barr Virus
3. Heart Failure
2001
1. Alzheimer’s Disease
2. Chronic Myelogenous Leukemia
3. SLE (Lupus)
2002
1. Heart Failure
2. Diabetes Mellitus
3. Preeclampsia
2003
1. SLE/Rheumatoid Arthritis
2. Chronic Myelogenous Leukemia
3. Asthma
2004
1. AIDS
2. Heart Failure
3. Preeclampsia
2005
1. Alzheimer’s Disease
2. Breast Cancer
3. Rheumatoid Arthritis
2006
1. Sickle Cell Anemia
2. Congestion Heart Failure
3. High Risk Pregnancy
2007
1. Rheumatoid Arthritis
2. Chronic Myelogenous Leukemia
3. Alzheimer’s Disease
2008
1. Cardio Disease/Heart Failure
2. Diabetes & Metabolism
3. Osteoporosis/Other Bone Disorders
2009
1. Sickle Cell Anemia
2. AIDS
3. Major Depressive Disorders
2010
1. Alzheimer’s Disease
2. Cardio Disease/Heart Failure
3. Diabetes
2011
1. Chronic Myelogenous Leukemia
2. Cystic Fibrosis
3. High Risk Pregnancy
2012
1. Rheumatoid Arthritis
2. Cardiovascular Disease
3. Malaria
2013
1. Diabetes
2. High Risk Pregnancy
3. Depression
2014
1. Translating Global Health
2. Cardiovascular Disease
3. Chronic Myelogenous Leukemia
2015
1. Immunotherapy
2. High Risk Pregnancy
3. Alzheimer’s Disease
2016
1. Evidence Based Medicine/Sickle Cell Disease
2. Diabetes
3. Cardiovascular Disease

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