• University of Minnesota-Twin Cities (2011)

  • Molecular Cell Biology

  • David G. DeNardo, Ph.D.

  • Tumor-Induced Changes in Dendritic Cell and Macrophage Populations

  • meyer.melissa@wustl.edu


Tumors dynamically interact with the host immune system to sculpt an immune microenvironment that is ideal for tumor progression. Systemically, tumors can alter differentiation of myeloid and dendritic cell populations. I am working to understand how tumor-induced changes alter dendritic cell populations to suppress an anti-tumor T cell response. Locally, macrophages can support tumor progression. To support this function, macrophages populations proliferate within the tumor. I am working to understand how local macrophage proliferation maintains macrophage number in the tumor, alters macrophage phenotype and, ultimately, supports tumor progression.

Last Updated: 8/28/2015 9:33:11 AM

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