Anne Elizabeth Robinson

  • Hope College (2012)

  • Biochemistry, Biophysics, and Structural Biology

  • Jeffrey P. Henderson, M.D., Ph.D.

  • Biochemical investigation of microbial transport processes.

  • anne.georges@wustl.edu

Research

I am interested in the mechanisms of membrane transporters. Our understanding of membrane proteins is restricted by the challenge of working with these insoluble, hydrophobic proteins. However, their location at the cell-environment interface renders membrane proteins of critical importance to the cell, making them appealing drug targets. In an era of increasing bacterial antibiotic resistance, an improved understanding of potential therapeutic targets is one of many strategies critical to developing future treatment options. I aim to implement a range of techniques from cellular to biochemical work to interrogate these important membrane transporters.

Graduate Publications:

Robinson AE, Heffernan JR, Henderson JP. The iron hand of uropathogenic Escherichia coli: the role of transition metal control in virulence. Future Microbiol. 2018 (13):745-756.
PMID: 29870278


Robinson AE, Henderson JP, and Henzler-Wildman KA. A mass spectrometry based transport assay for studying EmrE transport of unlabeled substrates. Anal. Biochem. 2018 (549):130–135.
PMCID: PMC5938110
PMID: 29559333

Robinson AE, Thomas NE, Morrison EA, Balthazor BM, and Henzler-Wildman KA. New free-exchange model of EmrE transport. Proc. Natl. Acad. Sci. USA. 2017 114(47):E10083-E10091. 10.1073/pnas.1708671114.
PMCID: PMC5703289
PMID: 29114048

Koh E-I, Robinson AE, Bandara N, Rogers BE, and Henderson JP. Copper import in Escherichia coli by the yersiniabactin metallophore system. Nat. Chem. Biol. 2017 13(9):1016-1021. 10.1038/nchembio.2441.
PMCID: PMC5562518
PMID: 28759019

Morrison EA, Robinsonb AE, Liu Y, and Henzler-Wildman KA. Asymmetric protonation of EmrE. J. Gen. Physiol. 2015 146(6):445-61.
PMCID: PMC4664823
PMID: 26573622

Last Updated: 7/9/2018 7:16:15 PM

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