• University of Evansville (2013)

  • Molecular Genetics and Genomics

  • S. Kerry Kornfeld, M.D., Ph.D.

  • Aging of the reproductive system in C. elegans.

  • zuzana@wustl.edu


The success of an organism is rooted in its ability to generate offspring that will survive and reproduce, but this capacity declines with age. Prominently, in C. elegans hermaphrodites, about one-third of adult lifespan is post-reproductive, even when sufficient sperm are provided by male mating (Hughes et al. 2007). Several mutants have been identified that display an extended mated reproductive span. While we have described quantitatively the progeny output of these mutants, the mechanism of reproductive span extension is unclear. We hypothesize that these mutants have delayed senescence of the germline.

Graduate Publications:

Kumar, S., Kocsisova, Z., & Kornfeld, K. (2014). Keep on Laying Eggs Mama, RNAi My Reproductive Aging Blues Away. PLoS Genetics, 10(12), e1004808. doi:10.1371/journal.pgen.1004808

Leung, W., ... Stamm, J., ...Kocsisova, Z. ... Elgin, S.C.R. (2015). Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution. G3: Genes| Genomes| Genetics, 5(5), 719-740. doi: 10.1534/g3.114.015966

Last Updated: 6/24/2015 9:15:50 AM

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