• Birla Institute of Technology and Science-Pilani (2013)

  • Molecular Cell Biology

  • David G. DeNardo, Ph.D.

  • Antigen presentation and cytotoxic T cell surveillance in pancreatic cancer

  • s.hegde@wustl.edu


Determining physiological barriers to CD8 T cell immunosurveillance in pancreatic cancer; using a combination of genetic/orthotopic murine models, ex vivo T cell-tumor interaction studies and in vitro T cell functionality assays.
[ NCI F99CA223043; FY2017-19 ]

Graduate Publications:

Jiang, H., Hegde, S., Knolhoff, B. L., Zhu, Y., Herndon, J. M., Meyer, M. A., et al. (2016). Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. Nature Medicine, 22(8), 851-860.

Jiang, H., Hegde, S., and DeNardo, D.G. (2017) Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy. Cancer Immunology Immunotherapy, 1-12. [Review]

Last Updated: 9/19/2017 12:58:36 PM

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