• Tsinghua University (2015)

  • Molecular Genetics and Genomics

  • Ting Wang, Ph.D.

  • Understanding the role of specific chaperone in stress response using yeast as a model

  • yiran@wustl.edu


Prions are aggregates of misfolded proteins which are infectious and pathogenic for various organisms. Studying underlying mechanism of prion formation may shed light on treatment for “prion-diseases” including Alzheimer’s disease. Since yeast can tolerate prions, and share basic mechanisms of protein synthetic and processing pathways with higher organisms, they serve as good systems to study prion.
My interests lie in endogenous chaperones and their role in prion formation and degradation process in yeast. In the ongoing project, I am trying to isolate the influence of each subunit in the nascent polypeptide-associated complex on prion propagation. Specifically, I am measuring the unfolded protein response of different NAC complex knockout strains triggered by exterior stress.

Last Updated: 9/23/2015 4:12:10 PM

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