Hannah Elizabeth Frye

  • Missouri University of Science and Technology (2015)

  • Neurosciences

  • Jose A. Moron-Concepcion, Ph.D.

  • The role of hippocampal cornichon homolog-3 in modulating AMPAR-dependent synaptic morphology and spatial learning

  • hfrye@wustl.edu


Glutamatergic AMPA receptors (AMPARs) are abundant neurotransmitter receptors in the brain which are tightly regulated by a diverse array of synaptic auxiliary proteins. One AMPAR auxiliary protein whose precise function in the brain remains largely unknown is cornichon homolog-3 (CNIH3). Prior studies of cornichon homologs predominately focus on CNIH2, but a recent genome-wide association study of heroin users identifies single nucleotide polymorphisms in CNIH3 correlated with protective effects against opioid dependence independent of CNIH2. CNIH3 is highly expressed in the hippocampus, a region where AMPAR activity regulates memory and learning. Based on prior studies of the effect of CNIH3 on hippocampal AMPAR activity and new evidence that CNIH3 may play a unique role in mammalian behavior, we hypothesize that CNIH3 regulates AMPAR-dependent memory and learning behavior through maintenance of AMPAR interactions with additional regulatory proteins at the post-synaptic density, controlling post-synaptic activity, which thereby mediates synapse density and morphology . Once we understand the cellular mechanisms of hippocampal CNIH3 responsible for mediating these behavioral outcomes, we plan to investigate the possible link between CNIH3 and opioid-associated memory and learning.

Last Updated: 7/11/2018 6:18:56 PM

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