Nancy L. Saccone, Ph.D. Assistant Professor Genetics Human and Statistical Genetics Program Molecular Genetics and Genomics Program Computational and Systems Biology Program
Office Phone: 314-747-3263 Lab Phone: Other Phone: FAX: 314-747-2489 Box: 8232 Lab Address: 308A Biotechnology Building Email: nlims@wustl.edu Keywords: genetics; substance abuse; linkage analysis; human disease gene mapping Short Research Description: Statistical genetics, complex human diseases, linkage analysis, association studies, analysis methods.
Research Abstract: My research focuses on using mathematical and statistical methods to study the genetics of complex traits in humans. Methods under development include use of linkage disequilibrium (LD) structure in the design and interpretation of disease association studies (e.g. tag SNP selection algorithms; leveraging LD differences in diverse populations to refine association signals). Applied projects focus on complex clinical diseases including substance dependence. To explain more of the risk for such diseases, we are developing alternative phenotypes and studying gene-gene and gene-environment interactions.
Selected Publications: Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research 2009 69: 6848-6856. Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ. In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genetics 2008 9: 58. Saccone SF, Saccone NL, Swan GE, Madden PAF, Goate AM, Rice JP, Bierut LJ. Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Bioinformatics 2008 24: 1805-1811. Saccone SF, Rice JP, Saccone NL. Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screens. Genet Epidemiol 2006 30: 459-470. Taillon-Miller P, Bauer-Sardina I, Saccone NL, et al. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet 2000 25: 324-328.

Last Updated: 09/02/2009