John P. Rice, Ph.D. Professor Psychiatry Mathematics Division of Biostatistics Human and Statistical Genetics Program
Office Phone: 314-286-2572 Lab Phone: Other Phone: FAX: 314-286-2577 Box: 8134 Lab Address: Biotechnology Building, Room 301 Email: john@zork.wustl.edu Keywords: mathematical modeling; epidemiology; genetics Short Research Description: Statistical genetics; complex disease genetics; methods in statistical genetics.
Research Abstract: Current research interests in my lab include the collection and analysis of GWAS data on the affective disorders and alcoholism as well as methodological development in genetic epidemiology. We head the data management portion of the Collaborative Study on the Genetics of Alcoholism (COGA), a six-site study to collect family, genetic linkage data and GWAS data. We also head the data management of the genotypic data for an NCI genetics study of Nicotine Dependence. We participate in a Gene Environment Initiative (GEI) on addiction and with the GAIN studies of Bipolar Disorder and Schizophrenia. We have grants and contracts for the NIDA, NIMH and NIA genetic repositories and are committed to data sharing as an important avenue for rapid progress. Our lab has a long history of methodologic contributions in the area of quantitative methods for genetic analysis, and has extensive experience with multi-site collaborative studies on the genetics of mental disorders. These efforts provide excellent opportunities for the use of data under the guidance of the providers of these data.
Selected Publications: Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Eskin E, Foroud T, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Murray SS, Nievergelt C, Nurnberger J, Nwulis EA, Paschall J, Potash JB, Rice JP, Schultze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Zöllner S, Schork NJ, Kelsoe JR. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 2009 14(8):755-763. PMID: 19488044 Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ. The CHRNA5-CHRNA3-CHRNB4 nicotonic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res 2009 Aug 25 (In Press). PMID: 19706762 SherSherva R, Rice JP, Neuman RJ, Rochberg N, Saccone NL, Bierut LJ. Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. Alcohol Clin Exp Res 2009 33(5):848-857. PMID: 19298322 Knight J, Saccone SF, Zhang Z, Ballinger DG, Rice JP. A comparison of association statistics between pooled and individual genotypes. Hum Hered 2009 67(4):219-225. PMID: 19172081 Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PAF, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, Fugman D, Martin NG, Montgomery GW, Wang JC, Ballinger DG, Rice JP, Bierut LJ. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007 16(1):36-49. PMCID: PMC2270437

Last Updated: 09/10/2009