John P. Rice, Ph.D. Professor Psychiatry Mathematics Division of Biostatistics Human and Statistical Genetics Program
Office Phone: 314-286-2572 Lab Phone: Other Phone: FAX: 314-286-2577 Box: 8134 Lab Address: Biotechnology Building, Room 301 Email: john@zork.wustl.edu Keywords: mathematical modeling; epidemiology; genetics Short Research Description: Statistical genetics; complex disease genetics; methods in statistical genetics.
Research Abstract: Current research interests in my lab include method development in genetic epidemiology and the collection and analysis of family data on the affective disorders, schizophrenia, smoking, alcoholism and other substance-use disorders. Methodologic work includes: (i) the development of new measures of linkage disequilibrium to define SNPs for association analysis; (ii) the use of the logistic regression model to incorporate covariates into linkage analysis; and (iii) the incorporation of follow-up data into genetic models to allow for diagnostic evaluations at multiple points in time. We will continue to apply these new techniques to a number of currently existing data sets. Our emphasis has been shifting from linkage analysis using several hundred repeat markers to association analysis using SNPs. We are expecting to get data from a case-control study of nicotine dependence in which 1.6 million SNPs are assayed in pools, followed by individual genotyping of approximately 20,000 SNPs. This new trend in the genetics of complex traits represents many challenges in data management and in analysis. We also maintain genetic repositories for NIMH, NIDA, NIAAA and NIA. Future emphasis will be the use of statistical genetics and bioinformatics for the meta-analysis of the genetic data available through these repositories.
Selected Publications: Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li T-K, Nurnberger Jr., JI, O’Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H. Variations in GABRA2, encoding the alpha 2 subunit of the GABAA receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 2004 74:705-714. Rice JP, Neuman RJ, Saccone NL, Corbett J, Rochberg N, Hesselbrock V, Bucholz KK, McGuffin P, Reich T. Age and birth cohort effects on rates of alcohol dependence. Alcohol Clin Exp Res 2003 27:93-99. Taillon-Miller P, Bauer-Sardina I, Saccone NL, Puetzel J, Laitinen T, Cao A, Kere J, Pilia G, Rice JP, Kwok PY. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nature Genets 2000 25:324-328. Rice JP, Rochberg N, Neuman RJ, Saccone NL, Liu KY, Zhang X, Culverhouse R. Covariates in linkage analysis. Genetic Epidemiology 1999 17:S691-S695. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, William Wu, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud TF, Nurnberger Jr J, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, Depaulo JR, Blehar MC, Reich T. Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12. Am J Med Genet (Neuropsych Genet) 1997 74:247-253.

Last Updated: 08/17/2006