Research Abstract:
The research focus of my lab is genetic dissection of complex traits, with particular emphasis on detecting genetic effects underlying one or more cardiovascular and metabolic pathways, involving gene-gene and gene-environment interactions. Specific research interests and activities include investigation of statistical genetics methodologies, collaborative family and genetic studies, and optimum study designs for genome-wide linkage and association studies. By serving as the Data Coordinating Center for several multi-center family and genetic studies, ready access is available to large and resourceful databases. These include the HyperGEN Study (http://www.biostat.wustl.edu/hypergen/hypergen.shtml), the Family Blood Pressure Program (http://www.biostat.wustl.edu/fbpp/FBPP.shtml), the GenSalt Family Study (http://www.biostat.wustl.edu/gensalt/gensalt.shtml), and the HERITAGE Family Study (http://www.biostat.wustl.edu/heritage/heritage.shtml). |
Selected Publications:
Yu K, Gu C, Province MA, Xiong CJ, Rao DC. Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genes. Genetic Epid 2004 27:182-191.
Gu C, Rao DC. Designing an optimum genetic association study using dense SNP markers and family-based sample. Frontiers in Biosci 2003 8:S68-S80.
Rao DC, Province MA, Leppert MF, Oberman A, Heiss G, Ellison RC, Arnett DK, Eckfeldt JH, Schwander K, Mockrin SC and Hunt SC. A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network. Amer J of Hypertension 2003 16:148-150.
Rao DC, Gu C. Principles and methods in the study of complex phenotypes In: Benjamin J, Ebstein R, Belmaker RH (Eds). Molecular genetics and human personality. 1st ed. Washington DC: American Psychiatric Press 2002 pgs 1-32.
Rao DC, Province MA. Genetic dissection of complex traits. San Diego: Academic Press 2001 pg 583. |