D.C. Rao, Ph.D.
Professor
Division of Biostatistics
Psychiatry
Genetics
Human and Statistical Genetics Program
Evolution, Ecology and Population Biology Program
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Office Phone: 314-362-3608
Lab Phone:
Other Phone:
FAX: 314-362-2693
Box: 8067
Lab Address: 706 S. Euclid Avenue, Room 1100
Email: rao@wubios.wustl.edu
Website: http://www.biostat.wustl.edu/faculty_staff/raodc.shtml
Keywords: epidemiology; mathematical modeling; genetics; obesity; heritability
Short Research Description: Statistical genetics, and genetic epidemiological investigations of cardiovascular disease and its co-morbidities, including interactions. |
Research Abstract:
The research focus of my lab is two-fold: novel method development for genetic dissection of complex traits involving gene-gene and gene-environment interactions, and, analysis of large real family datasets, including GWAS datasets. Specific research interests and activities include development of statistical genetics methodologies, collaborative family and genetic studies, and optimum study designs for genome-wide linkage and association studies. Most recent research focuses on methodological research for analysis of large GWAS datasets. By serving as the Data Coordinating Center for several multi-center family and genetic studies, ready access is available to large and resourceful databases. These include the HyperGEN Study (http://www.biostat.wustl.edu/hypergen/hypergen.shtml), the Family Blood Pressure Program (http://www.biostat.wustl.edu/fbpp/FBPP.shtml), the GenSalt Family Study (http://www.biostat.wustl.edu/gensalt/gensalt.shtml), and the HERITAGE Family Study (http://www.biostat.wustl.edu/heritage/heritage.shtml). |
Selected Publications:
Rao DC. An Overview of the Genetic Dissection of Complex Traits. Rao DC and Gu CC (eds). In “Genetic Dissection of Complex Traits”, 2nd Edition. Elsevier. New York, 2008, 3-34: 407-436.
Shi G and Rao DC. Ignoring Temporal Trends in Genetic Effects Substanially Reduces Power of Quantitative Trait Linkage Analysis. Genetic Epidemiology 2008 32: 61-72.
Sung YJ and Rao DC. Model-based linkage analysis with imprinting for quantative traits: Ignoring imprinting effects can severly jeopardize detection of linkage. Genetic Epidemiology (published 2008).
Rao DC, Gu C. Genetic dissection of complex traits. 2nd Edition, San Diego: Academic Press (Elsevier) 2008 pg 760. |