Research Abstract:
The primary area of investigation in our laboratory is the role of apoptosis after exposure of glioma cells to DNA-damaging agents in the treatment of brain tumors. We are correlating p53 and bcl-2 family gene expression in human glioma cell lines. More recently we have expanded studies to models of death in glioma cells. Methods include a variety of histological, cell culture, and fluorescent cell staining techniques. In vitro studies evaluate agents that influence neuronal or glioma cell death in a bioassay.
Selected Publications:
Vogelbaum MA, Tong JX, Perugu R, et al. Overexpression of BAX in human glioma cell lines. J Neurosurg 1999 91:483-489.
Vogelbaum MA, Tong JX, Higashikubo R, et al. Transfection of C6 glioma cells with the bax gene results in increased sensitivity to treatment with cytosine arabinoside. J Neurosurg 1998 88(1):99-105.
Vogelbaum MA, Tong JX, Rich KM. Developmental regulation of apoptosis in dorsal root ganglion neurons. J Neurosci 1998 18(21):8928-8935.
Rich KM, Tong JX. Flunarizine enhances survival and regeneration after sensory and motor peripheral nerve injury. Restor Neurol Neurosci 1997 11:203-209.
Tong JX, Vogelbaum MA, Rich KM. Radiation-induced apoptosis in dorsal root ganglions. J Neurocytol 1997 26:771-777.
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