Research Abstract:
Research in my laboratory is focused on the biology of ion channels, with emphasis on the molecular basis of potassium channel activity, and the role of potassium channels in physiology and disease. Using various molecular biological and biophysical approaches, we are developing a detailed understanding of the structural basis of channel activity. Using gene manipulation approaches, we are developing understanding of the role of potassium channels in disease processes in the heart, pancreas and other organs.
See more details and opportunities at our website (http://www.nicholslab.wustl.edu/)
Selected Publications:
Nichols CG. KATP channels as molecular sensors of cellular metabolism. Nature 2006 440:470-476.
Phillips LR, Enkvetchakul D, Nichols CG. Gating-dependence of inner pore access in inward rectifier K+ channels. Neuron 2003 37:953–962.
Koster JC, Marshall BA, Ensor N, et al. Targeted overactivity of b-cell KATP channels induces profound neonatal diabetes. Cell 2000 100:645-654.
Shyng SL, Nichols CG. Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 1998 282:1138-1141.
Lopatin AN, Makhina EN, Nichols CG. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 1994 372:366-369.
Last Updated: 08/05/2008 |