Research Abstract:
The long-term aim of our research is fourfold:
1) to determine the cellular circuitry responsible for the functional organization of sensory systems;
2) to uncover cellular and molecular principles controlling development of the mammalian peripheral and central nervous systems;
3) to assess the structural and functional consequences of peripheral and central nervous system injury;
4) to isolate effective strategies for repair of injuried neural tissue.
The rodent somatosensory system is being used as a model because of its stereotyped normal organization which lends itself to quantification, its known susceptibility to injury, and its clinical applications.
Selected Publications:
Jacquin MF, Arends JA, Xiang C, Shapiro LA, Ribak CE, Chen Z-F. In DRG11 knockout mice, trigeminal cell death is extensive and does not account for failed brainstem patterning. J Neurosci 2008 28:3577-3585.
Wang C-Z, Shi M, Yang L-L, Yang R-Q, Luo Z-G, Jacquin MF, Chen Z-F, Ding Y-Q. Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11. Mol Cell Neurosci 2007 35:368-376.
Erzurumlu RS, Chen Z-F, Jacquin MF. Molecular determinants of the face map development in the trigeminal Brainstem. Anat Rec A Discov Mol Cell Evol Biol 2006 288:121-134.
Howard MJ, Liu S, Schottler F, Snider BJ, and Jacquin MF. Transplantation of apoptosis-resistant embryonic stem cells into the injured rat spinal cord. Somatosens Mot Res 2005 22:37-44.
Ichikawa H, Matsuo S, Silos-Santiago I, Jacquin MF, and Sugimoto T. The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion. Acta Histochem 2004 106:337-343.
Last Updated: 08/13/2008 |