Research Abstract:
Research in our laboratory is aimed at elucidating the mechanisms of vascular and neuronal protection against CNS ischemic injury by a process called hypoxic preconditioning, wherein exposure to sublethal hypoxia promotes the activation of an endogenous protective phenotype in these cells. We also study inflammatory and oxidative mechanisms of vascular and neuronal injury in brain and retina of genetically engineered mice using videomicroscopic and other methods to directly visualize these injury processes. Cerebral endothelial cell cultures are also used as a concomitant in vitro model of ischemic injury and preconditioning-induced protection.
Selected Publications:
Wacker BK, Park TS, Gidday JM. Hypoxic preconditioning-induced cerebral ischemic tolerance: Role of microvascular sphingosine kinase 2. Stroke 2009 (In Press).
Stowe AM, Gonzales ER, Perez RS, Shah AR, Park TS, Gidday JM. Neutrophil elastase and neurovascular injury following focal stroke and reperfusion. Neurobiol. Dis. 2009 35: 82-90.
Zhu Y, Zhang L, Gidday JM. Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance. J. Ocular Pharmacol. Therap. 2008 24: 527-535.
Zhu Y, Zhang Y, Ojwang BA, Brantley Jr. MA, Gidday JM. Long-term tolerance to retina ischemia by repetitive hypoxic preconditioning: Role of HIF-1 alpha and heme oxygenase-1. Invest Ophthalmol Vis Sci 2007 48: 1735-1743.
Gidday JM. Cerebral preconditioning and ischemic tolerance. Nat Neurosci Rev 2006 7: 37-448.
Last Updated: 08/11/2009 |