Research Abstract:
Research in our laboratory is aimed at elucidating the mechanisms of vascular and neuronal protection against CNS ischemic injury by a process called hypoxic preconditioning, wherein exposure to sublethal hypoxia promotes the activation of an endogenous protective phenotype in these cells. We also study inflammatory and oxidative mechanisms of vascular and neuronal injury in brain and retina of genetically engineered mice using videomicroscopic and other methods to directly visualize these injury processes. Cerebral endothelial cell cultures are also used as a concomitant in vitro model of ischemic injury and preconditioning-induced protection.
Selected Publications:
Altay T, McLaughlin B, Wu JY, Park TS, Gidday JM. Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia. Exp Neurol In Press.
Zhang Y, Park TS, Gidday JM. Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Am J Physiol 2007 292:H2573-H2581.
Zhu Y, Zhang Y, Ojwang BA, Brantley Jr, MA, Gidday JM. Long-term tolerance to retina ischemia by repetitive hypoxic preconditioning: Role of HIF-1 alpha and heme oxygenase-1. Invest Ophthalmol Vis Sci 2007 48:1735-1743.
Gidday JM. Cerebral preconditioning and ischemic tolerance. Nat Neurosci Rev 2006 7:37-448.
Gidday JM, Gasche Y, Copin JC, et al. Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory following transient focal cerebral ischemia. Am J Physiol 2005 289:H558-H568.
Last Updated: 09/05/2007 |