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Human Pathobiology Courses |
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The majority of laboratories of Division of Biology and Biomedical Sciences faculty are physically on the School of Medicine campus and many of our faculty members are physician-scientists. This physical and intellectual integration of Ph.D. studies within the School of Medicine promotes curiosity about how even the most basic Ph.D. research project might have an impact on human disease and vice versa. Taking advantage of this relationship, we have developed a variety of courses and pathways to provide interested Ph.D. students the opportunity of exploring the clinical ramifications of fundamental problems in biology. We have designed these experiences to require varying degrees of commitment for students with different levels of interest and available time. Two pathways have been developed to provide students with extensive human pathobiology experiences. These are the Lucille P. Markey Special Emphasis Pathway in Human Pathobiology and the Cancer Biology Pathway. Both pathways offer a two year course of study. Selection will be made from students entering their 2nd year of graduate training. Click on the link to each pathway for additional information.
In addition to the courses offered by the pathways, the following courses are available to all students.
Pathobiology Courses
NEUROBIOLOGY OF DISEASE
Bio 5663
This is an advanced graduate seminar on the neuroscience of nervous system disorders. Students should have had some basic background study in Neurosciences. The class meets for 2½ hours each week. Each session is taught by a guest speaker with expertise in a specific neurological or psychiatric disease. In the first hour, the speaker discusses clinical manifestations and pathophysiology. Where possible the clinical presentation will be supplemented with a patient demonstration or videotape. The second hour follows a journal club format. Two or three students review current papers assigned by the speaker or course director. This course is offered in alternate years.
Examples of diseases discussed include the following: Alzheimer's disease, Multiple Sclerosis, Prion diseases, stroke, spinal cord injury, and Huntingdon's disease.
Additional information can be obtained at http://www.neuro.wustl.edu/bio5663.
MOLECULAR BASIS OF CANCER
Bio 5288
This is a one semester seminar course for advanced students in all Programs. The format is a mixture of didactic and journal club formats. Classes vary from the more basic to the more clinical in orientation.The course is currently offered every other year.
Topics related to cancer are discussed, including the following: the cell cycle, apoptosis, metastasis, genetics of cancer, tumor suppressor functions, drug resistance, and cancer vaccines.
SIGNAL TRANSDUCTION IN HUMAN BIOLOGY
Bio 5144
This is a one semester course for advanced students of all Programs. The format is a mixture of didactic and student presentations. State of the art experimental approaches and linkage between basic and clinical research will be highlighted, demonstrating how multidisciplinary research leads to understanding of disease mechanisms, improved diagnosis and treatment. Each section outlines the physiology and pathophysiology of relevant organ systems, the main signaling agents and pathways they regulate in target cells and tissues, and novel mechanistic principles that emerge.
Examples of topics covered include the following: cardiovascular disease, diabetes and obesity, pain, autoimmune disease, and leukemia.
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