Research Abstract:
My clinical interests focus on the interface between psychiatry and movement disorders. Areas of interest include traditionally psychiatric movement disorders (including Huntington's disease, Tourette syndrome, tardive dyskinesia, catatonia, motor signs in affective and psychotic disorders, and so-called psychogenic movement disorders) as well as psychological symptoms in traditionally neurological movement disorders (e.g. Parkinson's disease, Sydenham's chorea, Huntington disease, and dystonia). I am especially interested in the "pre-Tourette" period in children with tics, and in depression in Parkinson disease.
My imaging research is influenced by these clinical interests and is primarily focused on functional imaging of the dopaminergic system. In many diseases (e.g. idiopathic dystonia, schizophrenia, Tourette syndrome) there are a number of reasons to suspect a functional abnormality of dopamine-influenced basal ganglia circuits, yet many studies of specific elements of these pathways have been equivocal or negative. By giving a dopamine agonist, we "push on" these systems in a manner analogous to the clinical glucose challenge test, and we measure the response to the agonist using PET and functional MRI methods. Colleagues and I have applied this to studies of Parkinson's disease and Tourette syndrome. I recently developed a new method for single-session quantitative pharmacodynamic fMRI. Current NIH-funded research includes a test of this new method, and fMRI studies of Tourette syndrome.
Selected Publications:
Gordon MR, Markham J, Hartlein JM, Koller JM, Loftin S, Black KJ: Intravenous levodopa administration in humans based on a tracer kinetic model. J Neurosci Methods 2007 159:300-307. 16934332
Wang L, Lee DY, Bailey E, Hartlein JM, Gado MH, Miller MI, Black KJ. Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndrome. Psychiatry Res 2007 154:181-190. 17289354
Black KJ, Hershey T, Hartlein JM, Carl JL, Perlmutter JS. Levodopa challenge neuroimaging of levodopa-related mood fluctuations in Parkinson disease. Neuropsychopharmacology 2005 30:590-601. 15602502
Hershey T, Black KJ, Hartlein J, Barch DM, Braver TS, Carl JL, Perlmutter JS. Cognitive-pharmacologic fMRI in Tourette syndrome: A pilot study. Biol Psychiatry 2004 55:916-925. 15110735
Black KJ, Hershey T, Koller JM, Videen TO, Mintun MA, Price JL, Perlmutter JS: A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist. Proc Natl Acad Sci U S A 2002; 99(26):17113-17118. 12482941
Last Updated: 08/11/2009 |