Research Abstract:
Our research program focuses on the role of endogenous opioid peptides (EOP) in the control of hypothalamic-pituitary function. We are especially interested in the mechanisms by which EOP influence the release of hypothalamic releasing factors, particularly luteinizing hormone releasing hormone (LHRH), and the role these peptides play in the regulation of spermatogenesis and steroidogenesis in the testes.
In addition to our strong interest in the interaction between EOP and the endocrine system, we are also examining the influence of abused substances on neuroendocrine function. Our interests fall into two general areas. First, the effects of substances of abuse administered during the prepubescent period on the onset of puberty and sexual maturation. As an integral part of these studies we are also exploring the hypothesis that the maturation of the EOP system represents the “trigger” for the onset of puberty, which has thus far eluded identification.
Second, we have observed that the treatment of male rats with several abused compounds, such as morphine and alcohol, for a brief period of time followed by a drug free period, has adverse effects on their male and female offspring, particularly with respect to their neuroendocrine development and cognitive abilities. The mechanisms underlying these potentially important trans-generational effects of substances of abuse are actively under investigation. Our studies involve many levels of analysis: whole animal pharmacology, tissue culture, in vitro superfusion of various organs, biochemical analyses and a variety of other techniques in molecular biology.
Selected Publications:
Cicero TJ, Nock B, Meyer ER. Chronic exposure to morphine increases corticosteroid binding globuline. J Pharmacol Exp Ther 1997 282:1262-1268.
Cicero TJ, Nock B, Meyer ER. Gender-related differences in the antinociceptive properties of morphine. J Pharmacol Exp Ther 1996 279:767-773.
Adams, M.L.; Cicero, T.J. Alcohol, opioids and testicular function. In: Watson, R.R., editor. Drug and alcohol abuse reviews. Totowa, NJ: Humana Press Inc.; 1995. p. 279-294.
Cicero, T.J.; Adams, M.L. Opioid-mediated control of neuroendocrine function: Role of k, u and e receptors. In: Watson, R.R., editor. Drug and alcohol abuse reviews. Totowa, NJ: Humana Press Inc.; 1995. p. 21-47.
Cicero TJ, Nock B, O’Connor L, Adams ML, Meyer ER. Adverse effects of paternal opiate exposure on offspring development and sensitivity to morphine-induced analgesia. J Pharmacol Exp Ther 1995 273:386-392.
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