Research Abstract:
The objective of the Ances laboratory is to: 1) characterize HIV associated neurocognitive disorders (HAND) using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI); 2) assess the impact of combination antiretroviral therapy (cART) on BOLD fMRI. This work will delineate associations between cBOLD fMRI and surrogate cerebral spinal fluid (CSF) markers of inflammation and neuronal/glial injury. The ultimate goal is to create a non-invasive neuroimaging tool for early detection and treatment of HAND.
Selected Publications:
Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, Lansing AE, Buxton RB. Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation. Hum Brain Mapp. 2009 Apr; 30(4): 1120-32.
Ances BM, Bhatt A, Vaida F, Rosario D, Alexander T, Marquie-Beck J, Ellis RJ, Letendre S, Grant I, McCutchan JA. Role of metabolic syndrome components in human immunodeficiency virus-associated stroke.J Neurovirol. 2009 Jun 26: 1-8.
Letendre SL, Ellis RJ, Everall I, Ances B, Bharti A, McCutchan JA.Neurologic complications of HIV disease and their treatment. Top HIV Med. 2009 Apr-May; 17(2): 46-56.
Ances BM, Roc AC, Korczykowski M, Wolf RL, Kolson DL. Combination antiretroviral therapy modulates the blood oxygen level-dependent amplitude in human immunodeficiency virus-seropositive patients. J Neurovirol. 2008 Oct; 14(5): 418-24.
Ances BM, Leontiev OL, Perthen JE, Liang CL, Lansing A, Buxton RB. Regional Coupling Differences in Cerebral Blood Flow and Oxygen Metabolism: Implications for BOLD-fMRI. Neuroimage. 2008 39(4): 1510-21.
Last Updated: 08/12/2009 |