Kathleen B. Hall, Ph.D.

Biochemistry and Molecular Biophysics

Biochemistry, Biophysics, and Structural Biology Program

  • 314-362-4196

  • 314-362-8885

  • 314-362-7183

  • 8231

  • 2816 North Building

  • kathleenhal@gmail.com

  • http://www.biochem.wustl.edu/kbhlab/

  • RNA, NMR, RNA:protein interactions, fluorescence, thermodynamics

  • We study RNA folding and RNA binding to proteins

Research Abstract:

We study the structure and dynamics of RNA and RNA:protein complexes, with the goal of describing the basis of molecular recognition in these fascinating complexes. These studies use NMR, ITC, fluorescence, and computational methods, as well as biochemical techniques. We are also intrigued by the properties of RNA alone, and are using in vitro and computational methods to investigate the folding and dynamics of both small and larger RNAs.

Selected Publications:

Rau MJ, Welty R, Tom Stump W, Hall KB. Formation of Tertiary Interactions during rRNA GTPase Center Folding. J Mol Biol. 2015 Jul 22.

Rau MJ, Hall KB. 2-Aminopurine Fluorescence as a Probe of Local RNA Structure and Dynamics and Global Folding. Methods Enzymol. 2015;558:99-124.

DeKoster GT, Delaney KJ, Hall KB.(2014) A Compare-and-Contrast NMR Dynamics Study of Two Related RRMs: U1A and SNF. Biophys J. 107(1):208-19. PMID: 24988355.

Williams SG, Hall KB. (2014) Binding affinity and cooperativity control U2B″/snRNA/U2A` RNP formation. Biochemistry. 53(23):3727-37. PMID: 24866816; PMCID: PMC4067145.

Williams SG, Hall KB. (2014) Linkage and allostery in snRNP protein/RNA complexes. Biochemistry, 53(22):3529-39. PMID: 24849693; PMCID: PMC4059526.

Delaney KJ, Williams SG, Lawler M, Hall KB. (2014) Climbing the vertebrate branch of U1A/U2B″ protein evolution. RNA. 20(7):1035-45.PMID: 24840944;
PMCID: PMC4114683.

Hall KB. (2014) Molecular biology: Protein binding cannot subdue a lively RNA.Nature.506(7488):303-4.
PMID: 24522527; PMCID: PMC4052560.

Williams SG, Harms MJ, Hall KB. (2013) Resurrection of an Urbilaterian U1A/U2B″/SNF Protein. J Mol Biol. 425:3846-62. PMID:23796518

Rau M, Stump WT, Hall KB (2012) Intrinsic Flexibility of snRNA Hairpin Loops Facilitates Protein Binding. RNA 18(11):1984-95

Last Updated: 8/17/2015 10:52:33 AM

Back To Top

Follow us: