Arthur D. Loewy, Ph.D.

Professor
Neuroscience

Neurosciences Program

  • 314-362-3930

  • 314-362-3446

  • 8108

  • 903 McDonnell Medical Sciences Building

  • loewya@pcg.wustl.edu

  • http://neuroscience.wustl.edu/facultyPages/loewy.htm

  • autonomic functions, blood pressure regulation, sodium intake

  • CNS control of autonomic functions and sodium regulation

Research Abstract:

Basic life processes in the all mammals, including humans, are controlled by the autonomic nervous system. This neural network regulates the blood supply of all tissues of the body and adrenal gland, pancreas, and liver functions and modulates other types of visceral functions. Specific brain sites control this neural network. The primary goal of our research is to define the central brain sites that regulate blood pressure and sodium intake.

Selected Publications:

Goodwill VS, Terrill C, Hopewood I, Loewy AD, Knuepfer MM.(2016). CNS sites activated by renal pelvic epithelial sodium channels (ENaCs) in response to hypertonic saline in awake rats. Auton Neurosci. 2016 Sep 22. PMID: 27717709

Saper CB, Loewy AD, Swanson LW.(2016).Commentary on: Saper CB, Loewy AD, Swanson LW, Cowan WM. (1976) Direct hypothalamo-autonomic connections. Brain Research 117:305-312. Brain Res. 2016 Aug 15;1645:12-4. PMID: 26944298

Saper CB, Loewy AD.(2016). Commentary on: Efferent connections of the parabrachial nucleus in the rat. C.B. Saper and A.D. Loewy, Brain Research 197:291-317, 1980. Brain Res. 2016 Aug 15;1645:15-7.PMID: 26790347

Miller RL, Denny GO, Knuepfer MM, Kleyman TR, Jackson EK, Salkoff LB, Loewy AD.(2015). Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. PMID:25557402

Miller RL, Loewy AD.(2014). 5-HT neurons of the area postrema become c-Fos-activated after increases in plasma sodium levels and transmit interoceptive information to the nucleus accumbens. Am J Physiol Regul Integr Comp Physiol. 2014 May;306(9):R663-73. PMID: 24598462

Miller RL, Loewy AD.(2013). ENaC γ-expressing astrocytes in the circumventricular organs, white matter, and ventral medullary surface: sites for Na+ regulation by glial cells. J Chem Neuroanat. 2013 Nov;53:72-80. PMID: 24145067

Miller RL, Wang MH, Gray PA, Salkoff LB, Loewy AD.(2013). ENaC-expressing neurons in the sensory circumventricular organs become c-Fos activated following systemic sodium changes.Am J Physiol Regul Integr Comp Physiol. 2013 Nov 15;305(10):R1141-52. PMID: 24049115

Miller RL, Knuepfer MM, Wang MH, Denny GO, Gray PA, Loewy AD.(2012). Fos-activation of FoxP2 and Lmx1b neurons in the parabrachial nucleus evoked by hypotension and hypertension in conscious rats. Neuroscience. 2012 Aug 30;218:110-25.PMID: 22641087

Jansen AS, Nguyen XV, Karpitskiy V, Mettenleiter TC, Loewy AD. (1995).Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science. 1995 Oct 27;270(5236):644-6. PMID: 7570024




Last Updated: 10/17/2016 11:40:43 AM

Back To Top

Follow us: