Himadri B. Pakrasi, Ph.D.

Myron and Sonya Glassberg/Albert and Blanche Greensfelder Distinguished University Professor and Director
International Center for Energy, Environment and Sustainability (InCEES)

Plant and Microbial Biosciences Program
Biochemistry, Biophysics, and Structural Biology Program
Molecular Genetics and Genomics Program

  • 314-935-6853

  • 314-935-6862

  • 314-935-6803

  • 1095

  • McDonnell Hall 045; Office: Green Hall 1160B

  • Pakrasi@wustl.edu

  • https://sites.wustl.edu/photosynthbio/

  • Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology

  • Systems and Synthetic Biology of photosynthetic organisms

Research Abstract:

The Pakrasi Lab studies how cyanobacteria use solar energy to drive the chemistry of life.

We work in many disciplines and at many scales, studying how the molecular machines that capture solar energy are assembled and maintained, how cyanobacteria respond to changes in their environment at the systems level, and constructing new strains of cyanobacteria that can channel solar energy into biochemicals for human use.

Selected Publications:

Weisz, D. A., Liu, H., Zhang, H., Thangapandian, S., Tajkhorshid, E., Gross, M. L. and Pakrasi, H. B. (2017) Mass spectrometry-based cross-linking study shows that the Psb28 protein binds to cytochrome b559. Proc. Natl. Acad. Sci. USA, 114: 2224-2229.

Nguyen, A.Y., Bricker, W.P., Zhang, H., Weisz, D.A., Gross, M.L. and Pakrasi, H.B. (2017) Proteolysis Adaptor NblA Binds to the N-terminus of β-phycocyanin: Implications in the Mechanism of Phycobilisome Degradation. Photosynth. Res., 132: 95-106.

Chen, H-Y. S., Liberton, M. Pakrasi, H. B. and Niedzwiedzki, D. M. (2017) Reevaluating the Mechanism of Excitation Energy Regulation in Iron-Starved Cyanobacteria. Biochim. Biophys. Acta, 1858: 249-258.

Liberton, M., Chrisler, W., Nicora, C., Moore, R., Smith, R. D., Koppenaal, D. W., Pakrasi, H. B. and Jacobs, J. M. (2017) Phycobilisome Truncation Causes Widespread Proteome Changes in Synechocystis sp. PCC 6803. PLOS One 12: e0173251.

Ungerer, J.L. and Pakrasi, H.B. (2016) Cpf1 Is A Versatile Tool for CRISPR Genome Editing Across Diverse Species of Cyanobacteria. Scientific Rep., 6: 39681.

Wendt, K. E., Ungerer, J., Cobb, R. E., Zhao, H. and Pakrasi, H. B. (2016) CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973. Microbial Cell Factories, 15:115

Weisz, D. A., Gross, M. L. and Pakrasi, H. B. (2016) The use of advanced mass spectrometry to dissect the life-cycle of Photosystem II. Frontiers Plant. Sci, 7:167.

Saha, R., Liu, D., Hoynes-O`Connor, A., Liberton, M., Yu, J., Bhattacharyya-Pakrasi, M., Balassy, A., Zhang, F. Moon, T.-S., Maranas, C. D. and Pakrasi, H. B. (2016) A Systems Level Analysis of Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. PCC 6803. mBio, 7: e00464-16..

Liberton, M., Saha, R., Jacobs, J. M., Nguyen, A. Y., Gritsenko, M. A., Smith, R. D., Koppenaal, D. W. and Pakrasi, H. B. (2016) Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium. Mol. Cell. Proteomics, 15:2021-2032.

Ng, A. H., Berla, B. M. and Pakrasi, H. B. (2015) Fine tuning of photoautotrophic protein production by combining promoters and neutral sites in Synechocystis 6803, a cyanobacterium. Appl. Environ. Microbiol., 81: 6857-6863.

Liu, H., Zhang, H., Weisz, D. A., Vidavsky, I., Gross, M. L. and Pakrasi, H. B. (2014) Mass spectrometry based cross-linking analysis reveals the location of the PsbQ protein in cyanobacterial Photosystem II. Proc. Natl. Acad. Sci. USA, 111: 4638-4643.

Last Updated: 8/17/2017 10:55:15 AM

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