D.C. Rao, Ph.D.

Division of Biostatistics

Human and Statistical Genetics Program
Evolution, Ecology and Population Biology Program

  • 314-362-3608

  • 314-362-2693

  • 8067

  • 706 S. Euclid Avenue, Room 1100

  • rao@wubios.wustl.edu

  • https://biostatistics.wustl.edu/facultyandstaff/Pages/DCRao.aspx

  • genetic epidemiology, statistical genetics, hypertension, metabolic syndrome, interactions

  • Statistical genetic analysis of cardiovascular disease traits using GxG and GxE interactions

Research Abstract:

The research focus of my lab is genetic dissection of complex traits involving gene-gene and gene-environment interactions using large datasets, including GWAS, metabochip, Exome chip, and sequence datasets. Specific research activities include investigating sources of missing heritability for CVD traits using interactions, pathways, and rare variants in large collaborative family and genetic studies. By serving as the Data Coordinating Center for several multi-center family and genetic studies, ready access is available to large and resourceful databases. These include the HyperGEN Study (http://www.biostat.wustl.edu/hypergen/hypergen.shtml), the Family Blood Pressure Program (http://www.biostat.wustl.edu/fbpp/FBPP.shtml), the GenSalt Family Study (http://www.biostat.wustl.edu/gensalt/gensalt.shtml), and the HERITAGE Family Study (http://www.biostat.wustl.edu/heritage/heritage.shtml).

Selected Publications:

Sung YJ, Gu CC, Tiwari HK, Arnett DK, Broeckel U, Rao DC. Genotype Imputation for African Americans Using Data from HapMap Phase II versus 1000 Genomes Projects. Genetic Epidemiology, 36(5):508-516, 2012.

Wain LV, Verwoert GC, O’Reilly PF, Shi G, Johnson T . . . Munroe PB, Psaty BM, Caulfield MJ, Rao DC, Tobin MD, Elliot P, van Duijn CM (all the authors listed here contributed equally, among a total of 233 authors). Genome-Wide Association Study Identifies Six New Loci Influencing Pulse Pressure and Mean Arterial Pressure. Nature Genetics, 43(10): 1005-1011, 2011.

Shi G, Rao DC. Optimum Designs for Next-Generation Sequencing to Discover Rare Variants for Common Complex Disease. Genetic Epidemiology 35(6): 572-579, 2011.

Simino J, Shi G, Kume R, Schwander K, Province MA, Gu CC, Kardia S, Chakravarti A, Ehret G, Olshen RA, Turner ST, Ho LT, Zhu X, Jaquish C, Paltoo D, Cooper RS, Weder A, Curb JD, Boerwinkle E, Hunt, SC, Rao DC. Five Blood Pressure Loci Identified by an Updated Genome-Wide Linkage Scan: Meta-Analysis of the Family Blood Pressure Program. American Journal of Hypertension 2011 24(3): 347-354.

Shi G, Gu CC, Kraja AT, Arnett DK, Myers RH, Rankow J, Hunt SC and Rao DC. Genetic Effect on Blood Pressure is Modulated by Age: The Hypertension Genetic Epidemiology Network Study. Hypertension 2009 53(1): 35-41.

Sung YJ, Rice TK, Rao DC. Application of Collapsing Methods for Continuous Traits to the GAW 17 Exome Sequence Data. GAW 17, BMC Proceedings 2011 5(S9): S121.

Shi G, Simino J, Rao DC. Enriching Rare Variants Using Family-Specific Linkage Information. GAW 17, BMC Proceedings, 2011.

Sung YJ, Wang L, Rankinen T, Bouchard C, Rao DC. Performance of Genotype Imputations Using Data from the 1000 Genomes Project. Human Heredity, 73(1): 18-25, 2011.

Rao DC, Gu C. Genetic dissection of complex traits. 2nd Edition, San Diego: Academic Press (Elsevier) 2008 pg 760.

Last Updated: 7/29/2013 2:23:14 PM

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