Philip D. Stahl, Ph.D.

Edward Mallinckrodt Jr Professor Emeritus
Cell Biology and Physiology

General Program

  • 314-362-6913

  • 314-362-1081

  • 314-362-1490

  • 8228

  • 4912 South Building

  • pstahl@wustl.edu

  • human-specific genes, signal transduction, endocytosis

  • Hominoid-specific genes such as TBC1D3, that regulate growth factor receptor signaling, may explain why human physiology and pathobiology differs from lower species.

Research Abstract:

Hominoid-specific genes:
Delineating the cell and molecular biology of hominoid-specific genes- a virtually untouched field of investigation-will lay the foundation for understanding why humans are human- cell biologically, physiologically and psychologically. Until we discover and assemble a full accounting of these genes and their products, be it RNA or protein, we will not be in a position to fully understand human disease or the human condition. At the moment, there are dozens, possibly scores, of hominoid-specific genes. Some of these are under study by groups across the globe with special focus on brain development, immunity and infection, and reproduction. Our group has studied TBC1D3, a gene that evolved 25 million years ago and is only found in great apes and humans. TBC1D3 expression enhances growth factor receptor signaling by regulating ubiquitination and phosphorylation. Recent work from other groups suggests that TBC1D3 expression enhances neurogenesis in the developing human brain.

Exosomes:
Our laboratory discovered the exosome secretion pathway. This work, by Harding, Heuser and Stahl, along with a parallel paper by Rose Johnstone and colleagues, formed the basis for a new field of biomedical research –exosome biology. The biogenesis, secretion and targeting of exosomes is a major component of an emerging paradigm of “intercellular communication”. The exosome secretion pathway is predicted to have a major impact on our understanding of physiology, diagnostics and therapeutics.

Selected Publications:

Stahl PD, Wainszelbaum MJ. Human-specific genes may offer a unique window into human cell signaling. Sci Signal. 2009 2(89):pe59. http://www.ncbi.nlm.nih.gov/pubmed/19797272

Chen PI, Kong C, Su X, Stahl PD. Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors. J Biol Chem. 2009 284:30328-38. http://www.ncbi.nlm.nih.gov/pubmed/19723633

Wainszelbaum MJ, Charron AJ, Kong C, Kirkpatrick DS, Srikanth P, Barbieri MA, Gygi SP, Stahl PD. The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking. J Biol Chem. 2008 283:13233-42. http://www.ncbi.nlm.nih.gov/pubmed/18319245
Last Updated: 8/4/2011 12:26:12 PM


Lo Cicero A, Stahl PD, and Raposo G. Extracellular vesicles shuffling intercellular messages: for good or for bad. Curr. Opin. Cell Biol. 2015 35:69-77. doi: 10.1016/j.ceb.2015.04.013.

Harding CV, Heuser JE, and Stahl PD. Exosomes: looking back three decades and into the future. J Cell Biology. 2013 200(4):367-71. doi: 10.1083/jcb.201212113.

Last Updated: 8/4/2011 12:26:12 PM

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