Herbert W. "Skip" Virgin, M.D., Ph.D.

Edward Mallinckrodt Professor and Chair
Pathology and Immunology
Molecular Microbiology

Immunology Program
Human and Statistical Genetics Program
Molecular Microbiology and Microbial Pathogenesis Program

  • 314-362-9223

  • 314-362-9224

  • 314-362-4096

  • 8118

  • 1754 West Building

  • virgin@wustl.edu

  • http://pathology.wustl.edu/faculty/index.php?user=832&pageload=indi

  • immunology, virome, autophagy, inflammation, interferon, pathogenesis, microbiome, virology

  • We study viral immunology, the virome, search for new pathogens, and define the mechanisms of human disease genes..

Research Abstract:

We study issues at the interface between virology and immunology, working from the hypothesis that viruses manipulate the immune response using immunoevasive gene products as the immune response attempts to eradicate the virus. The resulting delicate balance determines the fate of both virus and host, and contributes to both acute and chronic disease. To understand the basis of human diseases of unknown etiology we have an active pathogen discovery program that has identified a number of novel viruses.

Selected Publications:

Orchard, R., C. B. Wilen, C. A. Nelson1, J. G. Doench, M. T. Baldridge, B. T. McCune, Y. J. Lee, S. Lee, S. Miller, D. H. Fremont, H. W. Virgin. Discovery of a proteinaceious cellular receptor for a norovirus. 2016. Science. In Press.

Moon, C., M. T. Baldridge, M. A. Wallace, C.-A. D. Burnham, H. W. Virgin*, T. S. Stappenbeck*. Vertically transmissible fecal IgA levels distinguish extra-chromosomal phenotypic variation. 2015. Nature. 521:90-3. PMID: 25686606; PMCID: PMC4425643. *co-corresponding authors.

Nice, T. J., M. T. Baldridge, B. T. McCune, J. M. Norman, H. M. Lazear, M. Artyomov, M. S. Diamond and H. W. Virgin. Interferon λ cures persistent murine norovirus infection in the absence of adaptive immunity. 2015. Science. 347(6219):269-73. Epub 2014 Nov 27. PMID: 25431489. PMCID: PMC4398891.

Baldridge, M. T., T. J. Nice, B. T. McCune, C. C. Yokoyama, A. Kambal, M. Wheadon, M. S. Diamond, Y. Ivanova, M. Artyomov and H. W. Virgin. Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection. 2015. Science. 347(6219):266-9. Epub 2014 Nov 27. PMID: 25431490. PMCID: PMC4409937.

Osborne L.C., L. A. Monticelli, T. J. Nice, T. E. Sutherland, M. C. Siracusa, M. R. Hepworth, V. T. Tomov, D. Kobuley, S. V. Tran, K. Bittinger, A. G. Bailey, A. L. Laughlin, J. L. Boucher, E. J. Wherry, F. D. Bushman, J. E. Allen, H. W. Virgin, D. Artis. Virus-helminth coinfection reveals a microbiota- independent mechanism of immunomodulation. 2014. Science. 345(6196):578-82. PMID 25082704. PMCID: PMC4548887.

Reese, T. A., B. S. Wakeman, H. S. Choi, M. M. Hufford, S. C.C. Huang, X. Zhang, M. D. Buck, A. Jezewski, A. Kambal, C. Y. Liu, G. Goel, P. J. Murray, R. J. Xavier, M. H. Kaplan, R. Renne, S. H. Speck, M. N. Artyomov, E. J. Pearce, and H. W. Virgin. Helminth Co-infection Reactivates Gammaherpesvirus Infection Through Viral Promoter-targeted Cytokine Competition. 2014. Science. 345(6196):573-7. PMID 24968940. PMCID: PMC4531374.

MacDuff, D. A., T. A. Reese, J. Kimmey, L. Weiss, C. Song, X. Zhang, A. Kambal, E. Duan, J. Carrero, B. Boisson, E. Laplantine, A. Israel, C. Picard , M. Colonna, B. T. Edelson, L. D. Sibley, C. Stallings, J.-L. Casanova, K. Iwai, and H. W. Virgin. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. 2015. eLife. 4:e04494. PMID: 25599590. PMCID: PMC4298697.

Norman, J. M., S. A. Handley, M. T. Baldridge, L. Droit, C. Y. Liu, B. C. Keller, A. Kambal, C. L. Monaco, G. Zhao, P. Fleshner, T. S. Stappenbeck, D. P. B. McGovern5, A. Keshavarzian, E. A. Mutlu, J. Sauk, D. Gevers, R. J. Xavier, D. Wang, M. Parkes and H. W. Virgin. Disease-specific Alterations in the Enteric Virome in Inflammatory Bowel Disease. 2015. Cell. 160:447-68. PMID: 25619688. PMCID: PMC4312520.

Wobus, C. E., S. M. Karst, L. Thackray, K.-O. Chang, S. V. Sosnovtsev, G. Belliot, A. Krug, J. M. Mackenzie, K. Y. Green, and H. W. Virgin. replication of a Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. 2004. PLOS Biology. E432. PMID: 15562321. PMCID: PMC532393.

Karst, S.M., Wobus, C. E., Lay, M., Davidson, J., and H. W. Virgin. STAT1-dependent innate immunity to a Norwalk-like virus. 2003. Science. 299(5612):1575-8. PMID 12624267.

Last Updated: 9/16/2016 9:19:36 AM

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