Charles F. Zorumski, M.D.

Samuel B. Guze Professor and Head
Psychiatry
Professor
Neuroscience

Neurosciences Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-747-2680

  • 314-362-8658

  • 314-747-2682

  • 2208 Renard Hospital

  • zorumskc@psychiatry.wustl.edu

  • synapse biology, ion channel, glutamate, GABA

  • Modulation of excitatory and inhibitory synaptic transmission

Research Abstract:

Glutamate and GABA are the major excitatory and inhibitory neurotransmitters in the mammalian central nervous system, playing roles in a variety of physiological and pathological processes. On the one hand these agents function in normal synaptic transmission; yet alterations in these systems can have profound consequences leading to seizures and neuronal damage.

Our laboratory is interested in the physiology and pharmacology of amino acid neurotransmitters with emphasis on the regulation of fast excitatory and inhibitory synaptic function. In our studies, we use whole cell voltage clamp and isolated patch recording techniques to examine modulation of the N-methyl-D-aspartate (NMDA) and non-NMDA (kainate/AMPA) classes of glutamate receptors on postnatal rat hippocampal neurons and hippocampal slices. Other studies in the lab are examining factors contributing to short- and long-term forms of synaptic plasticity in the hippocampus and the effects of neuroactive steroids and oxysterols on GABA and glutamate channels.

Selected Publications:

Warikoo N, Brunwasser S, Benz AM, Shu H-J, Paul S, Lewis M, Doherty J, Quirk M, Piccio L, Zorumski CF, Day G, Mennerick S: Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis. Journal of Neuroscience 2018; 38: 3218-3229. PMID: 29476014

Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM: The role of T-type calcium channels in the subiculum: to burst or not to burst? Journal of Physiology (London) 2017; 595: 6327-6348. PMCID: PMC5621493

Izumi Y, Zorumski CF: Neuregulin and dopamine D4 receptors contribute independently to depotentiation of Schaffer collateral LTP by temeroammonic path stimulation. eNeuro pii: ENEURO.0176-17; DOI: 10.1523/ENEURO.0176-17, 2017. PMCID: PMC5563842.

Zorumski CF, Izumi Y, Mennerick S: Ketamine: NMDA receptors and beyond. Journal of Neuroscience 2016; 36: 11158-11166. PMCID: PMC5148235

Sun M-Y, Izumi Y, Benz A, Zorumski CF, Mennerick SJ: Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices. Journal of Neurophysiology 2016; 115: 1263-1272. PMCID: PMC4808088

Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S: Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. British Journal of Pharmacology 2015; 172: 1333-1347. PMCID: PMC4337705

Izumi Y, Zorumski CF: Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function. Neuropharmacology 2014; 86: 273-281. PMCID: PMC4188808

Zorumski CF, Mennerick S, Izumi Y: Acute and chronic effects of ethanol on learning-related synaptic plasticity. Alcohol 2014; 48: 1-17. PMCID: PMC3923188

Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S: Neurosteroids, stress and depression: potential therapeutic opportunities. Neuroscience and Biobehavioral Reviews 2013; 37: 109-122. PMCID: PMC3591791

Zorumski CF, Izumi Y: NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders. Neuroscience and Biobehavioral Reviews 2012; 36: 989-1000. PMCID: PMC3288588

Last Updated: 7/24/2018 2:16:18 PM

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