Colin G. Nichols, Ph.D.
Carl Cori Professor
Cell Biology and Physiology
Molecular Cell Biology Program
Neurosciences Program
Biochemistry, Biophysics, and Structural Biology Program
314-362-6630
314-362-6629
314-362-7463
8228
9401 BJCIH
cnichols@wustl.edu
http://www.nicholslab.wustl.edu/nichols.htm
ion channel, neurobiology, functional genomics, cell signaling, kinetics
Ion channel biology in health and disease
Research Abstract:
Research in my laboratory is focused on the biology of ion channels, with emphasis on the molecular basis of potassium channel activity, and the role of potassium channels in physiology and disease. Using various molecular biological and biophysical approaches, we are developing a detailed understanding of the structural basis of channel activity. Using gene manipulation approaches, we are developing understanding of the role of potassium channels in disease processes including diabetes, cardiac arrhythmias and epilepsy.
Selected Publications:
Cheng WW, Enkvetchakul D, Nichols CG. KirBac1.1: it`s an inward rectifying potassium channel. J Gen Physiol. 2009 Mar;133(3):295-305.
Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG. Secondary consequences of beta cell inexcitabilit. Cell Metab. 2009 Feb;9(2):140-51.
Nichols CG. KATP channels as molecular sensors of cellular metabolism.
Nature 2006 440:470-476.
Phillips LR, Enkvetchakul D, Nichols CG. Gating-dependence of inner pore access in inward rectifier K+ channels. Neuron 2003 37:953–962.
Koster JC, Marshall BA, Ensor N, et al. Targeted overactivity of b-cell KATP channels induces profound neonatal diabetes. Cell 2000 100:645-654.
Last Updated: 4/12/2012 11:14:12 AM