Gary J. Weil, M.D.

Professor
Internal Medicine
Infectious Diseases
Molecular Microbiology

Molecular Microbiology and Microbial Pathogenesis Program

  • 314-747-5198

  • 314-747-5198

  • 314-454-5293

  • 8051

  • Room 4184, 4444 Forest Park Blvd, St. Louis, MO 63110

  • gweil@dom.wustl.edu

  • http://id.wustl.edu/our-people/faculty.html?layout=edit&id=91

  • gene expression, epidemiology, functional genomics, parasitology

  • Research on the biology of filarial nematode parasites

Research Abstract:

The Weil laboratory conducts research on filarial nematode parasites that cause important tropical diseases such as lymphatic filariasis and "river blindness". Our work is focused on the development and field application of improved diagnostic tests, on developing improved therapies, and on basic parasite biology. For example, we (with others) have developed new diagnostic tests for filariasis based on detection of parasite antigens, parasite DNA, and human antibodies to recombinant parasite antigens. Ongoing field studies are exploring the value of these newer tests for monitoring the impact of mass treatment programs on filariasis prevalence rates and transmission. We are also using genoproteomic approaches to develop new diagnostic tests for other helminthic diseases. Basic research in the laboratory is currently focused altered gene expression in worm parasites and in infected humans following treatment. We are also studying the role of Wolbachia (endosymbiotic bacteria) on filarial worm survival and development.

Selected Publications:

Li BW, McNulty SN, Zhen QR, Gu KZ, Weil GJ, Mitreva M. Characterization and comparison of the transcriptome of adult Paragonimus westermai and Skrjabina reveal pathways and molecules associated with host-parasite interactions. Parasites & Vectors, 2016, in press.

Vlaminck J, Fischer PU, Weil GJ. Diagnostic tools for onchocerciasis elimination programmes. Trends Parasitol 2015;31;571-582.

Li BW, Rush AC, Weil GJ. Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms. Int J Parasitol: Drugs and Drug Resistance. 2015;5:100-109.

Fischer PU, Weil GJ. North American Paragonimiasis: Epidemiology and diagnostic strategies. Expert Rev Anti Infect Ther 2015:13:779-786.

Li BW, Rush AC, Weil GJ. High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms. Int J Parasitol: Drugs and drug resistance 2014;4:71-76.

Fischer K, Beatty WL, Weil GJ, Fischer PU. High pressure freezing/freeze substitution fixation improves the ultrastructural assessment of Wolbachia endosymbiont–filarial nematode host interaction. PLoS One 2014;9:e86383.

McNulty SN, Abubucker S, Simon GM, Mitreva M, McNulty NP, Fischer K, Curtis KC, Brattig NW, Weil GJ, Fischer PU. Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer. PLoS One 2012;7:e45777.

Rao RU, Huang Y, Abubucker S, Heinz M, Crosby SD, Mitreva M, Weil GJ. Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo. J Biomed Sci 2012;19:21.

Li BW, Wang Z, Rush AC, Mitreva M, Weil GJ. Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi. BMC Genomics, 2012:13:184.

Fischer PU, Kurtis KC, Marcos LA, Weil GJ. Molecular characterization of the North American lung fluke Paragonimus kellicotti in Missouri and its development in Mongolian gerbils. Am J Trop Med Hyg 2011 84: 1005-1011.

Last Updated: 8/29/2016 11:53:53 AM

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