Sándor J. Kovács, Ph.D., M.D.

Professor
Internal Medicine
Cardiology
Adjunct Professor
Physics
Biomedical Engineering

Biochemistry, Biophysics, and Structural Biology Program

  • 314-362-8901

  • 314-454-7614

  • 314-362-0186

  • 8086

  • 4939 Children’s Place, Clinical Science Research Building

  • sjk@wuphys.wustl.edu

  • http://CBL1.wustl.edu

  • biophysics, cardiology, cardiovascular physiology, echocardiography, imaging, mathematical modeling

  • Quantitative cardiovascular physiology, mathematical modeling of systems physiology, imaging

Research Abstract:

Cardiovascular physiologic signals (pressures, flow, velocities, volumes) and static and/or dynamic images (echo, cath, MRI, CT) contain a wealth of information about the physical, biological and material attributes of the system. Only a minute amount of the total information in these signals is utilized for characterization of the presence and severity of disease, and essentially none of the information is used to gain a deeper understanding of the basic principles by which the components work as a system, or how the physiology and pathophysiology can be quantitatively characterized in terms of basic causal laws that can be expressed mathematically.

The Cardiovascular Biophysics Laboratory research group pursues a multi-disciplinary program encompassing selected aspects of physiology, biophysics, engineering, physics and clinical medicine. The overall goal is to solve basic and applied problems in physiology and medicine using a multidisciplinary approach, to discover “new” physiology, and to advance the frontiers of diagnosis and therapy. Areas of interest include: theoretical biology and physiology, characterization of the kinematic and material properties of cardiovascular tissue and its relation to matrix biology, 4-chamber heart function, diastolic function, ventriculo-arterial impedance, maximization of information extraction from physiologic signals, mathematical modeling of cardiovascular function and its in-vivo verification, and development of new technology for imaging and physiologic signal acquisition and processing.

Selected Publications:

Ghosh E, Kovcs SJ. The quest for load-independent left ventricular chamber properties: Exploring the normalized pressure phase plane. Physiological Reports 2013 (In Press)

Apor A, Merkely B, Morrell T, Zhu S, Ghosh E, Vg H, Andrssy P, Kovcs SJ. Diastolic Function in Olympic Athletes vs. Controls: Stiffness and Relaxation Based Echocardiographic Comparison. Journal of Exercise Science & Fitness. 11(1): 29-34, 2013.

Ghosh E, Kovcs SJ. Early Left Ventricular Diastolic Function Quantitation Using Directional Impedances. Annals BME. 41(6): 1269-1278, 2013.

Tger J, Kanski M, Carlsson M, Kovcs SJ, Sderlind G, Arheden H, Heiberg E. Diastolic vortex ring formation in the human left ventricle: quantitative analysis using Lagrangian coherent structures and 4D cardiovascular magnetic resonance velocity mapping. J of Cardiovascular Magnetic Resonance 2012, 14:W30.

Ghosh E, Kovcs SJ. Spatio-temporal attributes of left ventricular pressure decay rate during isovolumic relaxation. Am J Physiol Heart Circ Physiol. 302(5): H1094-1101, 2012.

Mossahebi S, Shmuylovich L, Kovcs SJ. The thermodynamics of diastole: kinematic modeling based derivation of the P-V loop to transmitral flow energy relation, with in-vivo validation. Am J Physiol Heart Circ Physiol. 300: H514-H521, 2011.

Ghosh E, Shmuylovich L, Kovcs SJ. The vortex formation time to left ventricular early, rapid filling relation: model based prediction with echocardiographic validation. J Appl Physiol. 109(6): 1812-1819, 2010.

Shmuylovich L, Chung CS, Kovcs SJ, Yellin E, Nikolic SD. Point-Counterpoint: Left ventricular volume during diastasis IS/IS NOT the physiologic in-vivo equilibrium volume and IS/IS NOT related to diastolic suction? Journal of Applied Physiology 2009 Dec 24. (JAPPL-01399-2009).

Shmuylovich L, Kovcs SJ. E-wave Deceleration Time May Not Provide an Accurate Determination of Left Ventricular Chamber Stiffness if Left Ventricular Relaxation/Viscoelasticity is Unknown. Am J Physiol Heart Circ Physiol. 292: H2712-H2720, 2007.

Shmuylovich L, Kovcs SJ. A load-independent index of diastolic filling: model-based derivation with in-vivo validation in control and diastolic dysfunction subjects. Journal of Applied Physiology, 2006;101: 92-101.

Last Updated: 7/29/2013 3:12:38 PM

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