Kelle H. Moley, M.D.

Professor
Obstetrics and Gynecology
Cell Biology and Physiology

Molecular Cell Biology Program
Developmental, Regenerative and Stem Cell Biology Program

  • 314-362-1765

  • 314-362-1997

  • 314-747-4150

  • 8064

  • BJCIH Bldg.,10th floor Suite 10617

  • moleyk@wustl.edu

  • http://www.obgyn.wustl.edu/moleylab/index.asp

  • autophagy, development, diabetes, germ cells, glucose transport, metabolism

  • Murine preimplantation embryogenesis: the effects of maternal hyperglycemia and hyperinsulinemia on glucose transporter and blastocyst survival

Research Abstract:

From animal and human studies it is clear that mammalian gametes and embryos are vulnerable to injury during the period of oocyte maturation as well as during pre-implantation stages of development. Maternal diabetes, insulin resistance, and obesity all have adverse effects on pregnancy outcome. Glucose transport and metabolism are critical for oocyte maturation, blastocyst formation and further development. These maternal metabolic conditions all perturb glucose utilization at all stages of development. The primary focus of my laboratory is on how these perturbations in mouse models translate into developmental abnormalities at a molecular level.

Current projects in the lab center around the themes of glucose transport, insulin signaling, maternal type 1 and type 2 diabetes and preimplantation embryos. They are as follows:
1. Maternal diabetes and oocyte quality
2. Insulin and IGF-1 signaling in blastocyst stage embryos
3. Fetal origins of adult diseases
4. GLUTs expression and Akt/ERK signaling in endometrium and non-genomic effects of estrogen
5. Aberrant embryo autophagy leads to abnormal embryo development

Selected Publications:

Frolova A, Flessner L, Chi M, Kim ST, Foyouzi-Yousefi N, Moley KH. GLUT1 is differentially regulated by progesterone and estrogen in murine and human endometrial stromal cells. Endocrinology 2009 150:1512-1520.

Kim ST & Moley KH. Regulation of facilitative glucose transporters and AKT/PRKAA/MAPK signaling via estradiol and progesterone in the murine uterine epithelium. Biology of Reproduction 2009 81:188-198.

Flessner L & Moley KH. Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese Hamster Ovary Cells. Traffic 2009 10:324-333.

Wang Q, Ratchford AM, Chi MM, Schoeller E, Frolova A, Schedl T, Moley KH. Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol Endocrinol. 2009 Oct;23(10):1603-12. Epub 2009 Jul 2.

Evans SA, Doblado M, Chi MM, Corbett JA, Moley KH. Facilitative Glucose Transporter 9 (GLUT9) expression affects glucose sensing in pancreatic beta cells. Endocrinology. 2009 Dec;150(12):5302-10. Epub 2009 Oct 6.

Last Updated: 8/4/2011 11:09:01 AM

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