Mark S. Conradi, Ph.D.


Biochemistry, Biophysics, and Structural Biology Program

  • 314-935-6418

  • 314-935-6292

  • 314-935-6219

  • 1105

  • rooms 64-76 Compton



  • helium-3, NMR, MRI, hyperpolarized, gas MRI, lungs, emphysema, COPD

  • Use hyperpolarized helium-3 and xenon-129 diffusion MRI to characterize lung microstructure

Research Abstract:

By hyperpolarizing the nuclear spins of helium-3 gas (or xenon-129), large MRI signals are available from the lung. The diffusion D of the gas is restricted by the walls of alveoli and acinar airways, so that measurement of D provides a description of the status of the lung microstructure, at a scale smaller than can be imaged directly. The size of alveoli and airways can be determined this way. Helium-3 D measurements have become the research standard for characterizing COPD.

An important future development will be the imaging of lungs of neonates, a group for whom breathing problems are life-threatening.

Selected Publications:

122. “Quantitative in vivo Assessment of Lung Microstructure at the Alveolar Level with Hyperpolarized 3He Diffusion MRI”, D. A. Yablonskiy, A. L. Sukstanskii, J. C. Leawoods, D. S. Gierada, G. L. Bretthorst,
S. S. Lefrak, J. D. Cooper, and Mark S. Conradi. Proceeding National Academy of Sciences 99. 3111-3116 (2002)

129. “Magnetization Tagging Decay to Measure Long-Range 3He Diffusion in Healthy and Emphysematous Canine Lungs”, J. C. Leawoods, D. A. Yablonskiy, K. Chino, T. S. K. Tanoli, J. D. Cooper, and Mark S. Conradi. Magn. Reson. Med. 51, 1002-1008 (2004)

135. “19F MR Imaging of Ventilation and Diffusion in Lungs”, R. E. Jacob, Y. Chang, C. Choong, A. Bierhals, D. Z. Hu, J. Zheng, D. A. Yablonskiy, J. C. Woods, D. S. Gierada, and Mark S. Conradi. Magnetic Resonance in Medicine 54, 577-585 (2005)

137. “Long-Range Diffusion of Hyperpolarized 3He in Excised Normal and Emphysematous Human Lungs via Magnetization Tagging”, J. C. Woods, C. K. Choong, D. A. Yablonskiy, K. Chino, P. T. Macklem, J. A. Pierce, J. D. Cooper, and M. S. Conradi. J. Appl. Physiology 99, 1992-1997 (2005)

142. “Hyperpolarized He-3 and Perfluorocarbon Gas Diffusion MRI of Lungs”, M. S. Conradi, B. T. Saam, D. A. Yablonskiy, and J. C. Woods. Progress in Nuclear Magnetic Resonance Spectroscopy 48, 63-83 (2006)

145. “Hyperpolarized 3He Diffusion MRI and Histology in Pulmonary Emphysema”, J. C. Woods, C. K. Choong, D. A. Yablonskiy, J. Bentley, J. Wong, J. A. Pierce, J. D. Cooper, P. T. Macklem, M. S. Conradi, and J. C. Hogg. Magn. Reson. Med. 56, 1293-1300 (2006)

155. “Role of Collateral Paths in Long-Range Diffusion in Lungs”, S. E. Bartel, S. E. Haywood, J. C. Woods, Y. V. Chang, C. Menard, D. A. Yablonskiy, D. S. Gierada, and M. S. Conradi. J. Applied Physiology 104, 1495-1503 (2008).

170. “Quantification of Lung Microstructure with Hyperpolarized 3He Diffusion MRI”, D.A. Yablonskiy, A.L. Sukstanskii, J.C. Woods, D.S. Gierada, J.D. Quirk, J.C. Hogg, J.D. Cooper, and M.S. Conradi. J. Applied Physiology 107, 1258-1265 (2009).

177. “Imaging Lung Microstructure in Mice with Hyperpolarized 3He Diffusion MRI”, W. Wang, N.M. Nguyen, D.A. Yablonskiy, A.L. Sukstanskii, E. Osmanagic, J.J. Atkinson, M.S. Conradi, and J.C. Woods. Magn. Reson. Med. 65, 620-626 (2011).

184. “Morphometric Changes in the Human Pulmonary Acinus during Inflation”, A.J. Hajari, D.A. Yablonskiy, A.L. Sukstanskii, J.D. Quirk, M.S. Conradi, and J.C. Woods. J. Appl. Physiology, 112, 937-943 (2012).

Last Updated: 1/29/2013 11:25:10 AM

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