Linda J. Sandell, Ph.D.

Professor
Orthopaedic Surgery

Molecular Cell Biology Program

Research Abstract:

Dr. Sandell’s laboratory focuses on gene regulation of extracellular matrix proteins and its influence on the phenotype of cells. Of particular interest is the role of transcriptional and post-transcriptional mechanisms of regulation of protein expression in the differentiation of mesenchymal cell phenotypes such as cartilage, bone, muscle and adipose. The Sandell laboratory has also had a long-standing interest in cellular mechanisms associated with chondrogenesis and endochondral bone formation and the discovery of new related extracellular matrix proteins and the interplay of positive and negative factors that regulate their expression. These anabolic and catabolic control mechanisms are of direct concern to the current understanding of the major cartilage disease, osteoarthritis. Arising from our interest in cartilage, recent studies have focused on understanding the molecular basis of inhibition of angiogenesis and tumors invasion in cartilage and the application of these findings to cancer and other diseases where neo-vascularization must be inhibited.

The Lab is recently focused on animal studies on the genetics of cartilage repair and regeneration particularly as it relates to future osteoarthritis. They have been able to demonstrate specific regions of the mouse genome as responsible for regeneration after wounding by ear hole punches and cartilage damage at a molecular, genetic and morphological level. Future studies will involve stem cells, fracture healing and gene array analysis of these animals. These studies are in collaboration with Dr. James Cheverud, Department of Anatomy.

Musculoskeletal Center http://musculoskeletalcore.wustl.edu/

Selected Publications:

Zhang Z, Xing X, Hensley G, Chang L, Liao W, Abu-Amer Y, Sandell LJ. Resistin induces expression of pro-inflammatory cytokines and chemokines in human articular chondrocytes via transcription and mRNA stabilization. Arthritis Rheumatism 2010 62(7): 1993-2003. PMID 20506172

Byers-Kraus V, Nevitt M and Sandell LJ. Summary of the OA Biomarkers Workshop 2009: Biochemical Biomarkers: Biology, Validation and Clinical Studies. Osteoarthritis and Cartilage 2010 18(6): 742-745.

Wang Z, Bryan J, Franz C, Havlioglu N and Sandell LJ. Type IIB procollagen NH2-Propeptide induces death of tumor cells via interaction with interaction with integrins αvB3 and αvB5. Journal Biological Chemistry 2010 Jul 285: 2006-20017.

Zhang Z, Bryan J, DeLassus E, Chang L-W, Liao W and Sandell LJ. CCAATT/Enhancer-binding protein β (C/EBPβ) and nuclear factor kappa B (NF-kB) mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to interleukin-1β (IL-1β). Journal Biological Chemistry 2010 Oct 285: 33092-33103.

Sanger TJ, Norgard EA, Pletscher LS, Bevilacqua M, Brooks VR, Sandell LJ and Cheverud JM. Developmental and genetic origins of murine long bone length variation. J Exp Zool B Mol Dev Evol. 2010 Dec 1. [Epub ahead of print]

Last Updated: 8/4/2011 12:02:04 PM

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