Michael L. Nonet, Ph.D.

Associate Professor
Neuroscience

Neurosciences Program
Molecular Genetics and Genomics Program

  • 314-747-1176

  • 314-362-8997

  • 314-362-3446

  • 8108

  • 958 McDonnell Medical Sciences Building

  • nonetm@wustl.edu

  • http://pcg.wustl.edu/nonetlab

  • synapse biology, genetics, Zebrafish, C. elegans, exocytosis

  • Molecular genetic analysis of synaptic development and function

Research Abstract:

My lab`s research is focused on understanding the molecular mechanisms that orchestrate the development, structural organization and secretory signaling functions of the presynaptic nerve terminal. Our general approach is to use a combination of genetics, physiology, pharmacology, molecular biology and cell biology to address these questions in genetically tractable model systems. See my website for a more comprehensive description of our research and publications.

Selected Publications:

Luo, S., Schaefer, A.M., Dour, S., & Nonet, M.L. (2014) The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synaptic maintenace in Caenorhaditis elegans. Development 141:3922-2933.

Zheng, Q., Ahlawat, S., Schaefer, A.M., Mahoney, T., Koushika, S., & Nonet, M.L.. (2014) The vesicle protein SAM-4 regulates the processivty of synaptic vesicle transport. PLoS Genetics. In Press.

Marcette, J., Chen, J.J., & Nonet, M.L. (2014). The C. elegans microtubule minus end binding homolog PTRN-1 stabilizes synapses and neurites. eLife 3:e01637.

Nonet M.L. (2012) A window into domain amplification through Piccolo in teleost fish. G3 2:1325-1339..

Zheng, Q., Schaefer, A.M. & Nonet, M.L. (2011) .Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10. Development 138: 87-96.

Mesa, R., Luo. S., Hoover, C.M., Miller, K., Minniti, A., Inestrosa, N., & Nonet, M.L. (2011). HID-1, a New Component of the Peptidergic Signaling Pathway. Genetics 187:467-83.

Bounoutas, A., Zheng, Q., Nonet, M.L., &Chalfie, M. (2009). mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development. Genetics 183: 607-17.

Mahoney, T.R., Luo, S., Round, E.K., Brauner, M., Gottschalk, A., Thomas, J.H. & Nonet, M.L. (2008) Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. PNAS 105: 16350-5.

Deken, S.L., Vincent, R., Hadwiger, G., Liu, Q., Wang, Z.W., &Nonet M.L. (2005). Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans. J Neurosci. 25: 5975-83.

Last Updated: 10/27/2014 12:01:50 PM

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