Mark Jacquin, Ph.D.
McMillan Hospital, 3rd Fl - Rm#301
development, injury, neurotrophins, pattern formation, sensory systems, transcription factors
Molecular mechanisms of mammalian sensory system development, plasticity and repair
The long-term aim of our research is fourfold:
1) to determine the cellular circuitry responsible for the functional organization of sensory systems;
2) to uncover cellular and molecular principles controlling development of the mammalian peripheral and central nervous systems;
3) to assess the structural and functional consequences of peripheral and central nervous system injury;
4) to isolate effective strategies for repair of injuried neural tissue.
The rodent somatosensory system is being used as a model because of its stereotyped normal organization which lends itself to quantification, its known susceptibility to injury, and its clinical applications.
Jacquin MF, Arends JA, Xiang C, Shapiro LA, Ribak CE, Chen Z-F. In DRG11 knockout mice, trigeminal cell death is extensive and does not account for failed brainstem patterning. J Neurosci 2008 28:3577-3585.
Wang C-Z, Shi M, Yang L-L, Yang R-Q, Luo Z-G, Jacquin MF, Chen Z-F, Ding Y-Q. Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11. Mol Cell Neurosci 2007 35:368-376.
Erzurumlu RS, Chen Z-F, Jacquin MF. Molecular determinants of the face map development in the trigeminal Brainstem. Anat Rec A Discov Mol Cell Evol Biol 2006 288:121-134.
Howard MJ, Liu S, Schottler F, Snider BJ, and Jacquin MF. Transplantation of apoptosis-resistant embryonic stem cells into the injured rat spinal cord. Somatosens Mot Res 2005 22:37-44.
Ichikawa H, Matsuo S, Silos-Santiago I, Jacquin MF, and Sugimoto T. The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion. Acta Histochem 2004 106:337-343.
Last Updated: 8/4/2011 10:07:21 AM