Fanxin Long, Ph.D.

Professor
Orthopaedic Surgery
Developmental Biology

Developmental, Regenerative and Stem Cell Biology Program
Molecular Cell Biology Program

  • 314-454-8795

  • 454-8794

  • 314-362-0334

  • 8233

  • BJC Institute of Health, 11th floor

  • flong@wustl.edu

  • Mesenchymal stem cells, Wnt, BMP, Hh, Notch, skeletal development, regeneration

  • Developmental and regenerative biology of the mammalian skeleton

Research Abstract:

Our general interest is in the development, homeostasis and regeneration of the mammalian skeleton. We are particularly interested in how bone marrow mesenchymal stem cells (MSC) are maintained and directed to differentiate along different lineages (e.g., osteoblast versus adipocytes) in vivo. We are also interested in how changes in these regulations contribute to skeletal diseases related to aging. An emerging theme in the lab is on the role of cellular metabolism in cell fate and function. Current projects include studies of the Hh, Wnt, Notch and BMP signaling pathways, as well as elucidation of MSC in vivo. We hope that our research can lead to novel strategies to treat osteoporosis and to improve fracture healing.

Selected Publications:

Courtney M. Karner, Emel Esen, Adewole L. Okunade, Bruce W. Patterson and Fanxin Long (2015). Increased glutamine catabolism mediates bone anabolism in response to Wnt signaling. JCI 125: 551-62

Jenna N. Regan, Joohyun Lim, Yu Shi, Kyu Sang Joeng, Jeffrey M. Arbeit, Ralph V. Shohet, Fanxin Long (2014). Upregulation of glycolytic metabolism is required for hypoxia-inducible factor-1α-driven bone formation. PNAS 111, 8673-8. PMC4060724

Jianquan Chen, Xiaolin Tu, Emel Esen, Kyu Sang Joeng, Congxin Lin, Jeffrey M Arbeit, Markus A. Ruegg, Michael N. Hall, Liang Ma and Fanxin Long (2014). Wnt7b promotes bone formation in part through mTORC1. PLoS Genet, 10(1): e1004145. doi: 10.1371/journal.pgen.1004145. PMC3907335.

Jianquan Chen and Fanxin Long (2014). mTORC1 signaling critically controls mammalian skeletal growth through stimulation of protein synthesis. Development 141, 2848-54. PMID: 24948603

Emel Esen, Jianquan Chen, Courtney M. Karner, Adewole L. Okunade, Bruce W. Patterson, Fanxin Long. WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metabolism 2013, http://dx.doi.org/10.1016/j.cmet.2013.03.017.

Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Julia Heisig, Cornelia Wiese, Kameswaran Surendran, Raphael Kopan, Manfred Gessler and Fanxin Long (2012). Physiological Notch signaling maintains bone homeostasis via RBPjk and Hey upstream of Nfatc1. PLoS Genet. 2012 Mar;8(3):e1002577. doi: 10.1371/journal.pgen.1002577. Epub 2012 Mar 22.

Kyu Sang Joeng and Fanxin Long. The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development 2009 136: 4177-85.

Ximei Wu, Xiaolin Tu, Kyu Sang Joeng, Matthew J. Hilton, David A. Williams, Fanxin Long. Rac1 activation controls nuclear localization of β-catenin during canonical Wnt signaling. Cell 2008 133(2): 340-53.

Matthew J. Hilton, Xiaolin Tu, Ximei Wu, Shuting Bai, Haibo Zhao, Tatsuya Kobayashi, Henry M. Kronenberg, Steven L. Teitelbaum, F. Patrick Ross, Raphael Kopan, Fanxin Long. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat. Med. 2008 14(3): 306-14.

Tu X, Joeng K-S, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP and Long F. Noncanonical Wnt signaling through G protein-linked PKCd activation promotes bone formation. Dev Cell 2007 12: 113-127.

Last Updated: 2/12/2015 9:32:16 AM

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