Philip V. Bayly, Ph.D.

The Lilyan & E. Lisle Hughes Professor and Chair
Mechanical Engineering & Materials Science
Biomedical Engineering

Neurosciences Program
Computational and Molecular Biophysics Program

  • 314-935-6081

  • 314-935-4014

  • 1185

  • pvb@wustl.edu

  • MR imaging of motion, mechanics of brain injury, impact, vibration, wave motion

  • The application of nonlinear dynamics and vibrations to mechanical and biomedical systems

Research Abstract:

My research involves the measurement and modeling of dynamic mechanical phenomena in biological systems. In collaboration with Jin-Yu Shao (biomedical engineering) and Susan Dutcher (genetics), I study flagellar waveforms and measure mechanical properties of flagella using an optical trap system. We are currently extending this approach to characterize the elastic properties and active behavior of human cilia. With Larry Taber (biomedical engineering) and Anders Carlsson, I have built mathematical models of the subcellular and tissue-scale biomechanical processes involved in morphogenesis. We have obtained quantitative measurements of deformation during development of the embryo, particularly the brain and eye. I study dynamic deformation and mechanical properties of the brain in the context of traumatic brain injury. These projects exploit advanced imaging methods and image processing techniques developed specifically to quantify dynamic physical processes; they all involve collaboration between engineers and medical or biological researchers.

Selected Publications:

Y. Feng, T.M. Abney, R.J. Okamoto, R.B. Pless, G.M. Genin, P.V. Bayly. Relative brain displacement and deformation during constrained mild frontal head impact. Journal of the Royal Society Interface. 2010 Dec 6; 7(53): 1677-88.

G. Xu, A.K. Knutsen, K. Dikranian, C.D. Kroenke, P.V. Bayly, L.A. Taber. Axons pull on the brain, but tension does not drive cortical folding. Journal of Biomechanical Engineering. 2010. 132(7):071013.

P. V. Bayly, B. L. Lewis, P. L. Kemp, R. B. Pless, S. K. Dutcher. Efficient spatiotemporal analysis of the flagellar waveform of Chlamydomonas reinhardtii. Cytoskeleton. 2010 67(1):56-69, 2009.

R. Namani, M.D. Wood, S.E. Sakiyama-Elbert, P.V. Bayly. Anisotropic mechanical properties of magnetically aligned fibrin gels measured by magnetic resonance elastography. Journal of Biomechanics, 42(13):2047-53. 2009.

Last Updated: 7/12/2013 9:32:45 AM

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