Division of Biology and Biomedical Sciences Campus Box 8226 660 S. Euclid Ave. St. Louis, MO 63110-1093
Main Phone Numbers: (314) 362-3365 (800) 852-9074
Associate ProfessorDivision of Biostatistics
Human and Statistical Genetics Program
314-362-3642
314-362-2693
8067
gc@wubios.wustl.edu
genetic epidemiology, statistical genetics
Statistical genetics and bioinformatics, high-dimensional data analysis and complex systems modeling, developing novel methodologies for detecting complex disease genes and characterizing their function
My current research is focused on the mathematical modeling of transmission of complex diseases. Ongoing research is aimed at the development of a unified framework for fine-mapping and cloning of disease loci by characterizing genetic contributions of individual loci so that detection of functional mutations in the laboratory is facilitated. This includes developing theoretical models and statistical methods to detect and map quantitative trait loci and to measure their effect sizes, devising computational algorithms to optimize study strategies, as well as analyzing actual data on specific diseases. In addition, we are conducting research on meta-analysis of genetic studies, in which evidences of genetic influence on a complex disease are quantitatively synthesized from a pool of studies to make a more congruent inference on the genetic etiology of the disease.
Last Updated: 8/3/2011 4:23:36 PM
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