Vijay Sharma, Ph.D.

Associate Professor
Radiology
Radiation Sciences

Biochemistry, Biophysics, and Structural Biology Program
Neurosciences Program

  • 314-362-9358

  • 314-362-9374

  • 314-362-0152

  • 8225

  • Sharma Laboratory, Bright Institute, 425 South Euclid, Room 7202, St. Louis, MO 63110

  • sharmav@wustl.edu

  • Molecular Imaging, PET and SPECT Agents, Myocardial Perfusion, Alzheimer`s Disease, Multidrug Resistance

  • Design and Development of Small Organics and Metalloprobes for Radiological Molecular Imaging in Biomedical Science

Research Abstract:

Molecular imaging enables visualization, characterization, and measurement of biological events (specifically relevant to diagnosis and therapeutic interventions) at both molecular and cellular levels in vivo. In the 21st century, molecular imaging is envisioned to play a pivotal role in drug development (determining target-sensitivity, -specificity, and dose efficacy), diagnosis and staging of disease states, identifying new biomarkers, and improving disease management (early diagnosis, new therapeutics, improving prognosis, and patient stratification). Our laboratory works at the interface of synthetic chemistry (organic and inorganic), medicinal chemistry (radiological molecular imaging), and biology. We design and develop molecular probes potentially capable of interrogating important biochemical pathways across multiple disciplines via interdisciplinary research. Some of the active research areas within our laboratory include the design and synthesis of small organic molecules and peptides for diagnosis of diseases, to understand protein-protein interactions via imaging of reporter gene expression in vivo, and employ these reagents to study biological mechanism(s). Additionally, our research interests include design and development of SPECT and PET tracers for probing the role of transporter-mediated drug resistance pathways in cancer biology, the blood-brain barrier, neurodegenerative diseases (Alzheimer’s Disease), and cardiovascular diseases (myocardial perfusion imaging).

Selected Publications:

Sundaram GS, Harpstrite SE, Kao JL, Collins SD, Sharma V. A New Nucleoside Analogue with Potent Activity against Mutant sr39 Herpes Simplex Virus-1 (HSV-1) Thymidine Kinase (TK). Org Lett. 2012, 14(14): 3568-3571.

Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath, NP, Sharma V. Synthesis, molecular structure, and validation of novel metalloprobes for assessment of MDR1P-glycoprotein-mediated functional transport. Dalton Trans. 2010, 39: 5842-5850.

Sivapackiam J, Gammon S, Harpstrite, SE, Sharma V. Targeted chemotherapy of drug resistant tumors, noninvasive imaging of P-glycoprotein (Pgp) mediated transport activity, and emerging role of Pgp in neurodegenerative diseases. Methods Mol. Biol. 2010, 596: 141-181.

Harpstrite SE, Prior JL, Rath, NP, Sharma V. Synthesis, characterization, and molecular structure of a novel zinc (II) complex: assessment of impact of MDR1Pgp expression on its cytotoxic activity. Med. Chem. 2010, 6:191-199.

Sharma V: Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity. Bioconjugate Chem. 2004, 15(6), 1464-1474.

Last Updated: 4/22/2013 9:35:36 AM

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