Tamara Hershey, Ph.D.


Neurosciences Program

  • 314-362-5593

  • 314-362-0168

  • 8225

  • 4525 Scott Ave, East Bldg

  • tammy@wustl.edu

  • http://hersheylab.wustl.edu/

  • neuroimaging, diabetes, hyperglycemia, hypoglycemia, Wolfram Syndrome, Parkinson disease, cognition, mood

  • Clinical neuroscience of diabetes and related diseases

Research Abstract:

Using neuroimaging (MRI, fMRI and PET) and behavioral techniques, we study:
1) how severe hypoglycemia and chronic hyperglycemia affect brain development in type 1 diabetes mellitus.
2) the neurodevelopmental and neurodegenerative changes in Wolfram syndrome
3) the relationship between obesity and dopamine receptors in the brain, their relationship to behavioral features and weight loss
4) how hyperglycemia and hyperinsulinemia affects regional brain glucose metabolism and functional connectivity in humans
5) how deep brain stimulation of the subthalamic nucleus affects cognitive and mood function in Parkinson disease

Selected Publications:

Siller AF, Lugar H, Rutlin J, Koller JM, Semenkovich K, White NH, Arbelaez AM, Shimony J, Hershey T (2017). Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure. Pediatr Diabetes; 18(8): 686-95. PMCID: PMC5290262

Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T, Washington University Wolfram Syndrome Research Study Group (2016). Neuroimaging evidence of deficient axon myelination in Wolfram syndrome. Sci Rep; 6: 21167. doi: 10.1038/srep21167. PMCID: PMC4758056

Eisenstein SA, Bogdan R, Corral-Frias NS, Koller JM, Black KJ, Moerlein SM, Perlmutter JS, Barch DM, Hershey T (2016). Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status. Synapse; 70(10): 418-31. PMCID: PMC4980198

Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM, Perlmutter JS, Black KJ, Hershey T (2016). Sweet dopamine: Sucrose preferences relate differentially to striatal D2 receptor binding and age in obesity. Diabetes; 65(9): 2618-23. PMCID: PMC5001180

Eisenstein SA, Bischoff AN, Gredysa DM, Antenor-Dorsey JA, Koller JM, Al-Lozi A, Pepino de Gruev MY, Klein S, Perlmutter J, Moerlein SM, Black KJ, Hershey T (2015). Emotional eating phenotype is associated with central dopamine D2 receptor binding independent of body mass index. Sci Report; 5: 11283. PMCID: PMC4464302

Eisenstein SA, Gredysa DM, Antenor-Dorsey J, Green L, Arbelaez AM, Koller JM, Black KJ, Perlmutter JS, Moerlein SM, Hershey T (2015). Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity. PlosOne; 10(7): e0133621. PMCID: PMC4507849

Eggebrecht AT, Ferradal SL, Robichaux-Viehoever A, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver JP (2014). Mapping distributed brain function and networks with diffuse optical tomography. Nat Photonics; 8(6): 448-54. PMCID: PMC4114252

Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T (2013). A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[11 C]methyl)benperidol. Synapse; 67(11): 748-56. PMCID: PMC3778147

Marshall BA, Permutt MA, Paciorkowski AR, Hoekel J, Karzon R, Wasson J, Viehover A, White NH, Shimony JS, Manwaring L, Austin P, Hullar TE, Hershey T, the Washington University Wolfram Study Group (2013). Phenotypic characteristics of early Wolfram syndrome. Orphanet J Rare Dis; 8(1): 64. PMCID: PMC3651298

Hershey T, Lugar H, Shimony J, Rutlin J, Koller JM, Perantie DC, Paciorkowski AR, Eisenstein SA, Permutt MA, the Washington University Wolfram Study Group (2012). Early brain vulnerability in Wolfram syndrome. PLoS One; 7(7): e40604. PMCID: PMC3394712

Last Updated: 7/27/2018 11:15:16 AM

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