Tamara Hershey, Ph.D.


Neurosciences Program

  • 314-362-5593

  • 314-362-0168

  • 8225

  • 4525 Scott Ave, East Bldg

  • tammy@wustl.edu

  • http://hersheylab.wustl.edu/

  • neuroimaging, diabetes, hyperglycemia, hypoglycemia, Wolfram Syndrome, Parkinson disease, cognition, mood

  • Clinical neuroscience of diabetes and related diseases

Research Abstract:

Using neuroimaging (MRI, fMRI and PET) and behavioral techniques, we study:
1) how severe hypoglycemia and chronic hyperglycemia affect brain development in type 1 diabetes mellitus.
2) the neurodevelopmental and neurodegenerative changes in Wolfram syndrome
3) the relationship between obesity and dopamine receptors in the brain, their relationship to behavioral features and weight loss
4) how hyperglycemia and hyperinsulinemia affects regional brain glucose metabolism and functional connectivity in humans
5) how deep brain stimulation of the subthalamic nucleus affects cognitive and mood function in Parkinson disease

Selected Publications:

Eisenstein SA, Bischoff AN, Gredysa DM, Antenor-Dorsey JA, Koller JM, Al-Lozi A, Pepino de Gruev MY, Klein S, Perlmutter J, Moerlein SM, Black KJ, Hershey T (2015). Emotional eating phenotype is associated with central dopamine D2 receptor binding independent of body mass index. Sci Report; 5: 11283. PMCID: PMC4464302

Eisenstein SA, Gredysa DM, Antenor-Dorsey J, Green L, Arbelaez AM, Koller JM, Black KJ, Perlmutter JS, Moerlein SM, Hershey T (2015). Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity. PlosOne; 10(7): e0133621. PMCID: PMC4507849

Eggebrecht AT, Ferradal SL, Robichaux-Viehoever A, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver JP (2014). Mapping distributed brain function and networks with diffuse optical tomography. Nat Photonics; 8(6): 448-54. PMCID: PMC4114252

Cato MA, Mauras N, Ambrosino J, Bondurant A, Conrad AL, Kollman C, Cheng P, Beck RW, Ruedy KJ, Aye T, Reiss AL, White NH, Hershey T, Diabetes Research in Children Network (DirecNet) (2014). Cognitive functioning in young children with type 1 diabetes. J Int Neuropsychol Soc; 20(2): 238-47. PMCID: PMC4123061

Arbeláez AM, Semenkovich K, Hershey T (2013). Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain. Pediatr Diabetes; 14(8): 541-53. PMCID: PMC3857606

Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T (2013). A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[11 C]methyl)benperidol. Synapse; 67(11): 748-56. PMCID: PMC3778147

Marshall BA, Permutt MA, Paciorkowski AR, Hoekel J, Karzon R, Wasson J, Viehover A, White NH, Shimony JS, Manwaring L, Austin P, Hullar TE, Hershey T, the Washington University Wolfram Study Group (2013). Phenotypic characteristics of early Wolfram syndrome. Orphanet J Rare Dis; 8(1): 64. PMCID: PMC3651298

Antenor-Dorsey JA, Meyer E, Rutlin J, Perantie D, White NH, Shimony J, Hershey T (2013). White matter microstructural integrity in youth with type 1 diabetes. Diabetes; 62(2): 581-9. PMCID: PMC3554385

Hershey T, Lugar H, Shimony J, Rutlin J, Koller JM, Perantie DC, Paciorkowski AR, Eisenstein SA, Permutt MA, the Washington University Wolfram Study Group (2012). Early brain vulnerability in Wolfram syndrome. PLoS One; 7(7): e40604. PMCID: PMC3394712

Last Updated: 12/31/2015 11:43:34 AM

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