Phillip I. Tarr, M.D.
Melvin E. Carnahan Professor
Gastroenterology & Nutrition
Molecular Microbiology and Microbial Pathogenesis Program
6103 McDonnell Pediatrics Research Building
bacteriology, evolution, genome analysis, inflammation, microbial pathogenesis
Pathogenic interactions between microbes and the gut
We are focusing on the microbial milieu of the human host in an attempt to determine the pathogenesis of diarrheal illnesses, and to determine the cause of unexplained diarrhea. We also focus our efforts in depth on the pathophysiology of progression to extra-intestinal injury in Escherichia coli O157:H7 infections. Additionally, we are studying the evolution of the chromosomes of pathogenic microbes. We are also interrogating human microbial interactions in inflammatory bowel disease.
Bennett WE Jr, González-Rivera R, Puente BN, Shaikh N, Stevens HJ, Mooney JC, Klein EJ, Denno DM, Draghi A, Sylvester FA, Tarr PI. Proinflammatory fecal mRNA and childhood bacterial enteric infections. Gut Microbes 2010 (In Press).
Leopold SR, Shiakh N, Tarr PI. Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7. Infection, Genetics and Evolution 2010 (In Press).
Bennett WE Jr, González-Rivera R, Shaikh N, Magrini V, Boykin M, Warner BB, Hamvas A, Tarr PI. A method for isolating and analyzing human mRNA from newborn stool. J Immunol Methods. 2009 Sep 30;349(1-2):56-60. Epub 2009 Aug 3. PubMed PMID: 19660464; PubMed Central PMCID: PMC2850193.
Leopold SR, Magrini V, Holt NJ, Shaikh N, Mardis ER, Cagno J, Ogura Y, Iguchi A, Hayashi T, Mellmann A, Karch H, Besser TE, Sawyer SA, Whittam TS, Tarr PI. A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8713-8. Epub 2009 May 13. PubMed PMID: 19439656; PubMed Central PMCID: PMC2689004.
Finkbeiner SR, Allred AF, Tarr PI, Klein EJ, Kirkwood CD, Wang D. Metagenomic analysis of human diarrhea: viral detection and discovery. PLoS Pathog. 2008 Feb 29;4(2):e1000011. PubMed PMID: 18398449; PubMed Central PMCID: PMC2290972.
Last Updated: 8/4/2011 12:55:03 PM