Sharon Cresci, M.D.

Assistant Professor
Internal Medicine
Cardiology

Human and Statistical Genetics Program
Computational and Systems Biology Program
Molecular Genetics and Genomics Program

  • 314-362-5363

  • 314-362-8921

  • 314-747-8560

  • 8086

  • CSRB0 9926-9928

  • scresci@wustl.edu

  • cardiovascular disease, diabetes melitus, genotype, genetic variation

  • Genetic variation in the variable response to pharmacologic treatment (i.e. Pharmacogenomics) of cardiovascular disease; specifically individuals with both diabetes mellitus and coronary artery disease.

Research Abstract:

My research focuses on the association of genetic variation with clinical outcomes in patients with cardiovascular disease and on the role of genetic variation in the variable response to pharmacologic treatment (i.e. Pharmacogenomics) of cardiovascular disease. My specific interest is in individuals with both diabetes mellitus and coronary artery disease. The goal of my research is to ultimately be able to personalize each patient’s treatment based on their genotype.

Selected Publications:

Cresci S. ADRB1 variants in atrial fibrillation: small steps and giant leaps toward personalized therapy in cardiovascular disease. J Am Coll Cardiol. 2012 Jan 3;59(1):57-9. No abstract available. PMID: 22192669

Morgan TM, House JA, Cresci S, Jones P, Allayee H, Hazen SL, Patel Y, Patel RS, Eapen DJ, Waddy SP, Quyyumi AA, Kleber ME, März W, Winkelmann BR, Boehm BO, Krumholz HM, Spertus JA. Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Med Genet. 2011 Sep 29;12:127. PMID: 21957892

Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG; BARI 2D Study Group. Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial. Circulation. 2011 Sep 27;124(13):1426-34. Epub 2011 Sep 12. PMID: 21911782

Lanfear DE, Jones PG, Cresci S, Tang F, Rathore SS, Spertus JA. Factors influencing patient willingness to participate in genetic research after a myocardial infarction. Genome Med. 2011 Jun 15;3(6):39. PMID: 21676259

Gong Y, Beitelshees AL, Cooper-DeHoff RM, Lobmeyer MT, Langaee TY, Wu J,Cresci S, Province MA, Spertus JA, Pepine CJ, Johnson JA. Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease. Circ Cardiovasc Genet. 2011 Apr;4(2):169-78. Epub 2011 Mar 3. PMID: 21372283

Last Updated: 9/17/2012 11:38:16 AM

Back To Top

Follow us: