S.-K. "Victor" Song, Ph.D.

Radiation Sciences

Neurosciences Program

Research Abstract:

The development of diffusion MRI derived biomarker of white matter injury and function has been the primary research goal of Song lab. We have recently developed a novel diffusion basis spectrum imaging (DBSI) to distinguish and quantitatively assess various components of CNS nerve pathology. Specifically, DBSI is capable of distinguishing inflammation associated cellular infiltration and vasogenic edema, axonal injury, and demyelination. More recently, we have also demonstrated that DBSI detects brain and prostate tumors quantifying cellularity and edema contents associated with tumor growth. Currently, we have translated DBSI to human imaging brain, optic nerve, and spinal cord pathologies in patients of multiple sclerosis. In addition, DBSI has also been applied to image spinal cord damages in patients with spinal cord injury (SCI) or cervical spondylotic myelopathy (CSM) patients assessing the extent of irreversible axonal loss noninvasively. Other human translation of DBSI including brain tumor, stroke, traumatic brain injury (TBI), prostate cancer (PCa), and Alzheimer’s disease. In addition to DBSI detection/quantification of CNS pathologies, we have also detected optic nerve function using diffusion weighted MRI. Currently, we are performing both in vivo and in silico stuides to understand how functional activation of axons changes diffusion of water molecules. An in vitro perfused nerve system is currently being developed to establish a dose response relationship between the extent of electric stimulation of sciatic/optic nerves and apparent diffusion coefficient (ADC) changes. We will combine what we have learned from DBSI and diffusion function MRI of CNS nerves to develop a new diffusion MRI-based method to assess optic nerve anatomy, function and pathology simultaneously in both mice and human. Our goal is to establish such method to image function and pathology of axons in the human brain.

Selected Publications:

1. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage. 2002 Nov; 17 (3):1429-36. PubMed PMID: 12414282.
2. Song SK, Qu Z, Garabedian EM, Gordon JI, Milbrandt J, Ackerman JJ. Improved magnetic resonance imaging detection of prostate cancer in a transgenic mouse model. Cancer Res. 2002 Mar 1;62(5):1555-8. PubMed PMID: 11888935.
3. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003 Nov;20(3):1714-22. PubMed PMID: 14642481.
4. Song SK, Yoshino J, Le TQ, Lin SJ, Sun SW, Cross AH, Armstrong RC. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage. 2005 May 15;26(1):132-40. PubMed PMID: 15862213.
5. Xu J, Humphrey PA, Kibel AS, Snyder AZ, Narra VR, Ackerman JJ, Song SK. Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans. Magn Reson Med. 2009 Apr;61(4):842-50. PubMed PMID: 19215051; PubMed Central PMCID: PMC3080096.
6. Wang Y, Wang Q, Haldar JP, Yeh FC, Xie M, Sun P, Tu TW, Trinkaus K, Klein RS, Cross AH, Song SK. Quantification of increased cellularity during inflammatory demyelination. Brain. 2011 Dec;134(Pt 12):3590-601. PubMed PMID: 22171354; PubMed Central PMCID: PMC3235568.
7. Spees WM, Lin TH, Song SK. White-matter diffusion fMRI of mouse optic nerve. Neuroimage. 2013 Jan 15;65:209-15. PubMed PMID: 23085108; PubMed Central PMCID: PMC3513522.
8. Chiang CW, Wang Y, Sun P, Lin TH, Trinkaus K, Cross AH, Song SK. Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. Neuroimage. 2014 Nov 1;101:310-9. PubMed PMID: 25017446; PubMed Central PMCID: PMC4165711.
9. Lin TH, Spees WM, Chiang CW, Trinkaus K, Cross AH, Song SK. Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis. Neurobiol Dis. 2014 Jul;67:1-8. PubMed PMID: 24632420; PubMed Central PMCID: PMC4035476.
10. Wang Y, Sun P, Wang Q, Trinkaus K, Schmidt RE, et al. Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis. Brain. 2015 Feb 26;PubMed PMID: 25724201.

Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/1Hg4a8fM9QRkn/bibliography/43336898/public/?sort=date&direction=descending

Last Updated: 8/31/2016 9:16:09 AM

Imaging optic nerve function and pathology
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