Gregory M. Lanza, M.D., Ph.D.

Professor
Internal Medicine
Cardiology Consultants

Biochemistry, Biophysics, and Structural Biology Program

  • 314-454-8813

  • 314-454-8635 (Sheila, secretary)

  • 314-454-5265

  • 8215

  • greg.lanza@me.com

  • imaging, molecular imaging, ultrasound, magnetic resonance spectroscopy, drug delivery

  • Noninvasive molecular imaging and drug delivery research

Research Abstract:

Our primary research interests are focused upon noninvasive molecular imaging and drug delivery research, i.e, tissue-specific imaging and therapy. We have developed and patented a novel, ligand-targeted, lipid-encapsulated, nongaseous perfluorocarbon emulsion for use with ultrasound, magnetic resonance and nuclear imaging modalities. This multidimensional platform technology also facilitates targeted drug delivery. Coupling molecular imaging with therapy allows quantification of drug delivered to a specific site. Current areas of molecular imaging and targeted drug delivery research include: 1) thrombosis and vulnerable atherosclerotic plaques; 2) arterial restenosis following angioplasty; 3) angiogenesis for solid tumor, atherosclerosis and wound healing; and 4) early detection of atherosclerosis, organ rejection and other inflammatory diseases.

Selected Publications:

RW, Wallace KD, Thomas T, Smith J, Agyem K, Lanza GM, Wickline SA: Real-time calculation of a limiting form of the Renyi entropy applied to detection of subtle changes in scattering architecture. J Acoust Soc Am 2009; 126(5): 2350-2358.

Lin WB, Hyeon T, Lanza GM, Zhang M, Meade TJ: Magnetic Nanoparticles for Early Detection of Cancer by Magnetic Resonance Imaging. MRS Bulletin 2009; 34(6): 441-448.

Senpan A, Caruthers SD, Rhee I, Mauro NA, Pan D, Hu G, Scott MJ, Fuhrhop RW, Gaffney PJ, Wickline SA, Lanza GM: Conquering the dark side: Colloidal iron oxide nanoparticles. ACS Nano 2009; 3(12): 3917-3926.

Pan D, Pramanik M, Senpan A, Ghosh S, Wickline SA, Wang LV, Lanza GM. Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons. Biomaterials 2010; 31(14): 4088-4093.

Kaneda MM, Sasaki Y, Lanza GM, Milbrandt J, Wickline SA: Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions. Biomaterials 2010; 31(11): 3079-3086.

Pan D, Caruthers SD, Chen J, Winter PM, Senpan A, Schmieder AH, Wickline SA, Lanza GM: Nanomedicine strategies for molecular targets with MRI and optical imaging. Future Med Chem 2010: 2(3): 471-490.

Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL: Imaging atherosclerosis and vulnerable plaque. J Nucl Med 2010: 51 (Suppl 1): 51S-65S

Kassner A, Thornhill RE, Liu F, Winter PM, Caruthers SD, Wickline SA, Lanza GM: Assessment of tumor angiogenesis: Dynamic contrast-enhanced MRI with paramagnetic nanoparticles compared with Gd-DTPA in a rabbit Vx-2 tumor model. Contrast Media Mol Imaging 2010; 5(3): 155-161.

Chen J, Lanza GM, Wickline SA: Quantitative magnetic resonance fluorine imaging: Today and tomorrow. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2010; 2(4): 431-440.

Winter PM, Caruthers SD, Allen JS, Cai K, Williams TA, Lanza GM, Wickline SA: Molecular imaging of angiogenic therapy in peripheral vascular disease with avb3-integrin-targeted nanoparticles. Magn Reson Med 2010; 64(2): 369-376.

Akers WJ, Zhang Z, Berezin M, Ye Y, Agee A, Guo K, Fuhrhop RW, Wickline SA, Lanza GM, Achilefu S: Targeting of α(ν)β(3)-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles. Nanomedicine (Lond) 2010; 5(5): 715-726.

Lanza GM, Winter PM, Caruthers SD, Hughes MS, Hu G, Schmieder AH, Wickline SA: Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions. Angiogenesis 2010; 13(2): 189-202.

Pan H, Myerson JW, Ivashyna O, Soman NR, Marsh JN, Hood JL, Lanza GM, Schlesinger PH, Wickline SA: Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures. FASEB J 2010; 24(8): 2928-2937.

Lanza GM, Caruthers SD, Winter PM, Hughes MS, Schmieder AH, Hu G, Wickline SA: Angiogenesis imaging with vascular-constrained particles: The why and how. Eur J Nucl Med Mol Imaging 2010; 37 (Suppl 1): S114-S126.

Marsh JN, Wallace KD, McCarthy JE, Wickerhauser MV, Maurizi BN, Lanza GM, Wickline SA, Hughes MS: Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors. IEEE Trans Ultrason Ferroelectr Freq Control 2010; 57(8): 1890-1895.

Cai K, Caruthers SD, Huang W, Williams TA, Zhang H, Wickline SA, Lanza GM, Winter PM: MR molecular imaging of aortic angiogenesis. JACC: Cardiovasc Imaging 2010; 3(8): 824-832.

Zhou H-F, Hu G, Wickline SA, Lanza GM, Pham CT: Synergistic effect of antiangiogenic nanotherapy combined with methotrexate in the treatment of experimental inflammatory arthritis. Nanomedicine 2010; 5(7):1065-1074.

Caruthers SD, Winter PM, Wickline SA, Lanza GM, Keupp J: MR molecular imaging of angiogenesis using targeted perfluorocarbon nanoparticles. Medica Mundi 2010; 54(2): 5-13.

Boles KS, Schmieder AH, Koch AW, Carano RAD, Wu Y, Caruthers SD, Tong RK, Stawicki S, Hu G, Scott MJ, Zhang H, Reynolds BA, Wickline SA, Lanza GM: MR angiogenesis imaging with Robo4-vs ανβ3-targeted nanoparticles in a B16/F10 mouse melanoma model. FASEB J 2010; 24(11): 4262-4270.

Winter PM, Caruthers SD, Lanza GM, Wickline SA: Quantitative cardiovascular magnetic resonance for molecular imaging. J Cardiovasc Magn Reson 2010; 12(1): 62.

Lanza GM, Marsh JN, Hu G, Scott MJ, Schmieder AH, Caruthers SD, Pan D, Wickline SA: Rationale for a nanomedicine approach to thrombolytic therapy. Stroke 2010; 41(10 Suppl): S42-44.

Pan D, Roessl E, Scholmka JP, Caruthers SD, Senpan A, Scott MJ, Allen JS, Zhang H, Hu G, Gaffney PJ, Choi ET, Rasche V, Wickline SA, Proksa R, Lanza GM: Computed Tomography in Color: NanoK-enhanced Spectral CT Molecular Imaging. Angew Chem Int Ed Engl 2010; 49(50): 9635-9639.

Pan D, Pramanik M, Senpan A, Wickline SA, Wang LV, Lanza GM: A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging. J Nanosci Nanotechnol 2010; 10(12): 8118-8123.

Pan H, Ivashyna O, Sinha B, Lanza GM, Ratner L, Schlesinger PH, Wickline SA: Post-formulation peptide drug loading of nanostructures for metered control of NF-κB signaling. Biomaterials 2011; 32(1): 231-238; PMCID: PMC2997356

Pham CTN, Mitchell LM, Huang JL, Lubniewski CM, Schall OF, Killgore JK, Pan D, Wickline SA, Lanza GM, Hourcade DE: Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces. J Biol Chem 2011; 286(1): 123-130; PMCID: PMC3012966

Hockett FD, Wallace KD, Schmieder AH, Caruthers SD, Pham CTN, Wickline SA, Lanza GM: Simultaneous dual frequency 1H and 19F open coil imaging of arthritic rabbit knee at 3T. IEEE Trans Med Imaging 2011; 30(1): 22-27; PMCID: PMC3047411

Pan D, Pramanik M, Senpan A, Allen JS, Zhang H, Wickline SA, Wang LV, Lanza GM: Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons. FASEB J 2011; 25(3): 875-882; PMCID: PMC3042842

Pan H, Soman NR, Schlesinger PH, Lanza GM, Wickline SA: Cytolytic peptide nanoparticles (NanoBees) for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011; 3(3): 318-327

Hughes M, Marsh J, Lanza G, Wickline S, McCarthy J, Wickerhauser V, Maurizi B, Wallace K: Improved signal processing to detect cancer by ultrasonic molecular imaging of targeted nanoparticles. JASA 2011; 129: 3756-3767.

Marsh JN, Hu G, Scott MJ, Zhang H, Goette MJ, Gaffney PJ, Caruthers SD, Wickline SA, Abendschein D, Lanza GM: A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke. Nanomedicine 2011; 6(4): 605-615.

Akers WJ, Kim C, Berezin M, Guo K, Fuhrhop R, Lanza GM, Fischer GM, Daltrozzo E, Zumbusch A, Ca X, Wang LV, Achilefu S: Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. ACS Nano 2011; 5:173-182.

Hu L, Hockett FD, Chen J, Zhang L, Caruthers SD, Lanza GM, Wickline SA: A generalized strategy for designing 19F/1H dual-frequency MRI coil for small animal imaging at 4.7 Tesla. J Magn Reson Imaging 2011; 34(1): 245-252.

Pan D, Caruthers SD, Senpan A, Yalaz C, Stacy AJ, Hu G, Marsh JN, Gaffney PJ, Wickline SA, Lanza GM: Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus. J Am Chem Soc 2011; 133(24): 9168-9171.

Pan D, Schmieder AH, Wickline SA, Lanza GM: Manganese-based MRI contrast agents: past, present, and future. Tetrahedron 2011; 67(44): 8431-8444

Keupp J, Rahmer J, Grasslin I, Mazurkewitz PC, Schaeffter T, Lanza GM, Wickline SA, Caruthers SD: Simultaneous Dual-Nuclei Imaging for Motion Corrected Detection and Quantification of 19F Imaging Agents. Magn Reson Med 2011; 66(4): 1116-1122.

Pan D, Pramanik M, Wickline SA, Lanza GM: Recent advances in colloidal gold nanobeacons for molecular photoacoustic imaging. Contrast Media Mol Imaging 2011; 6(5): 378-388.

Lanza GM: Emerging contrast agents for photoacoustic imaging. Contrast Media Mol Imaging 2011; 6(5): 331.

Last Updated: 12/11/2012 10:41:21 AM

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