Kooresh Isaac Shoghi, Ph.D.
Assistant Professor
Radiology
Radiation Sciences
Biomedical Engineering
Computational and Systems Biology Program
Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program
314-362-8990
8225
CSRB 4415
shoghik@wustl.edu
shoghilab.wustl.edu
biology of disease mechanisms, computational biology, engineering, imaging sciences
Multi-disciplinary research spanning biology of disease mechanisms, engineering and imaging sciences & informatics
Research Abstract:
The research interests of the Shoghi lab are cross-disciplinary spanning biology of disease mechanisms, engineering and imaging sciences & informatics. Current projects include multi-tissue metabolic phenotyping of diabetes and gender differences in heart disease and downstream complications. We also use computational biology and computational imaging to characterize and quantify biological processes such as metabolism and signal transduction pathways, among others, in-vivo, in health and disease. Image quantification is accomplished through mathematical and statistical modeling of multi-modality image data. We are also developing artificial tissue systems to enable discovery and validation of imaging and therapeutic biomarkers. Finally, to facilitate these efforts, our group is also working on image processing and quantification algorithms to integrate information across imaging modalities.
Selected Publications:
Tomlinson RE, Silva MJ, Shoghi KI. Quantification of Skeletal Blood Flow and Fluoride Metabolism in Rats using PET in a Pre-Clinical Stress Fracture Model. Mol Imaging Biol. 2011 Jul 22. [Epub ahead of print] PMID: 21785919
Tu Z, Fan J, Li S, Jones LA, Cui J, Padakanti PK, Xu J, Zeng D, Shoghi KI, Perlmutter JS, Mach RH. Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain. Bioorg Med Chem. 2011 Mar 1;19(5):1666-73. Epub 2011 Jan 22. PMID: 21315609
Su Y, Shoghi KI. Single-input-dual-output modeling of image-based input function estimation. Mol Imaging Biol. 2010 Jun;12(3):286-94. Epub 2009 Dec 1. PMID: 19949986
Shoghi KI. Quantitative small animal PET. Q J Nucl Med Mol Imaging. 2009 Aug;53(4):365-73. Review. PMID: 19834445
Shoghi KI, Finck BN, Schechtman KB, Sharp T, Herrero P, Gropler RJ, Welch MJ. In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy. Circ Cardiovasc Imaging. 2009 Sep;2(5):373-81. Epub 2009 Jul 21. PMID: 19808625
Last Updated: 7/22/2015 2:03:29 PM