Nada A. Abumrad, Ph.D.

Robert C. Atkins Professor of Obesity Research in Medicine
Internal Medicine
Nutritional Science

Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-747-0348

  • 314-362-8206

  • 8031

  • nabumrad@wustl.edu

  • fatty acids, obesity, diabetes

  • The molecular mechanisms regulating utilization of fatty acids

Research Abstract:

Dr Abumrad’s group researches the molecular mechanisms regulating utilization of fatty acids and how abnormalities in fatty acid metabolism can result in metabolic disease such as obesity and diabetes. She identified the plasma membrane protein CD36 as a facilitator of cellular fatty acid uptake and is now examining the role of CD36 in modulating tissue adaptation to nutrient fluctuations and other stresses. Mice models of tissue-specific variations in CD36 gene level are being studied but the goal is to translate findings in rodents to humans where polymorphisms in the CD36 gene are common. A current project in humans is exploring (in collaboration with Alan Permutt and Sam Klein) whether mutations in CD36 are associated with an increased risk of insulin resistance and diabetes.

Selected Publications:

Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012 Apr 19;484(7394):333-8. PMID: 22466288

Samovski D, Su X, Xu Y, Abumrad NA, Stahl PD. Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase. J Lipid Res. 2012 Apr;53(4):709-17. Epub 2012 Feb 6. PMID: 22315395

Pepino MY, Love-Gregory L, Klein S, Abumrad NA. The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J Lipid Res. 2012 Mar;53(3):561-6. Epub 2011 Dec 31. PMID: 22210925

Love-Gregory L, Abumrad NA. CD36 genetics and the metabolic complications of obesity. Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):527-34. Review. PMID: 21912245

Abumrad NA, Moore DJ. Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36. J Clin Invest. 2011 Sep;121(9):3389-92. doi: 10.1172/JCI59219. Epub 2011 Aug 25. PMID: 21865651

Tran TT, Poirier H, Clément L, Nassir F, Pelsers MM, Petit V, Degrace P, Monnot MC, Glatz JF, Abumrad NA, Besnard P, Niot I. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem. 2011 Jul 15;286(28):25201-10. Epub 2011 May 24. PMID: 21610069

Last Updated: 3/2/2007 12:00:00 AM

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