Robert T. Naismith, M.D.

Assistant Professor

General Program

Research Abstract:

Our clinical investigative team is dedicated to the use of imaging as a surrogate of clinical outcomes in multiple sclerosis. Multiple sclerosis is a disease of the central nervous system which can result in disability over years to decades. Clinical outcomes vary within individual patients, and often accumulate over an extended time. Surrogate markers are desired to predict prognosis, evaluate the effectiveness of our treatments, and to optimize the response to therapy.

Imaging has included brain, spinal cord, optica nerve, and retina. Quantitative MRI techniques have included diffusion tensor imaging, magnetization transfer imaging, and volumetric analyses. Clinical outcomes have included ambulation, vision, cognition, quality of life, upper extremity function, and other symptom batteries (e.g. pain, fatigue, depression).

Selected Publications:

Klawiter EC, Schmidt RE, Trinkaus K, Liang HF, Budde MD, Naismith RT, Song SK, Cross AH, Benzinger TL. Radial diffusivity predicts demyelination in ex-vivo multiple sclerosis spinal cords. Neuroimage 2011 55(4):1454-1460.

Klawiter EC, Xu J, Naismith RT, Benzinger TLS, Shimony JS, Lancia S, Snyder AZ, Trinkaus K, Song SK, Cross AH. Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared to multiple sclerosis. Multiple Sclerosis Journal 2012 (In Press).

Naismith RT, Xu J, Tutlam NT, Lancia S, Trinkaus K, Song SK, Cross AH. Diffusion Tensor Imaging in Acute Optic Neuropathies Predicts Clinical Outcomes. Arch Neurol. 2011 Sep 12. [Epub ahead of print]

Klawiter EC, Roy A, Benzinger T, Naismith RT, Parks BJ, Cross AH. Spinal cord ring enhancement in multiple sclerosis. Archives of Neurology 2010 67(10): 1395-1398.

Naismith RT, Piccio LP, Tutlam NT, Lauber J, Trinkaus K, Parks BJ, Song SK, Cross AH. Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: a 52-week phase II trial. Neurology 2010 74(23):1860-1867. PMID: 20530322 [PubMed - in process]

Naismith RT, Xu J, Tutlam NT, Trinkaus K, Cross AH, Song SK. Increased radial diffusivity in remote optic neuritis discriminates clinical visual outcomes. Neurology 2010 74:1702-1710. PMID: 20498438 [PubMed - in process]

Naismith RT, Xu J, Tutlam NT, Scully P, Snyder A, Trinkaus K, Song SK, Cross AH. Increased diffusivity in acute multiple sclerosis lesions predicts risk for progression to a persistent black hole. Neurology 2010 74:1694-1701. PMID: 20498437 [PubMed - in process]

Klawiter E, Cross AH, Naismith RT. The present efficacy of multiple sclerosis: is the new 66% just the old 33%. Neurology 2009 73:984-990. PMID: 19770475 [PubMed - indexed for MEDLINE] PMCID: PMC2754334

Piccio L, Naismith RT, Trinkaus K, Klein RS, Parks BJ, Lyons JA, Cross AH. Rituximab reduces B Cells, T Cells, and the Chemokines CXCL13 and CXCL19 in the Spinal Fluid in Multiple Sclerosis. Accepted at Archives of Neurology.

Newland PK, Naismith RT, Ullione M, Madsen R. The impact of pain and other symptoms on quality of life in women with relapsing-remitting multiple sclerosis. Journal of Neuroscience Nursing 2009 41(6):322-8. PMID: 19998683 [PubMed - indexed for MEDLINE].

Naismith RT, Tutlam NT, Xu J, Shepherd JB, Klawiter EC, Song SK, Cross AH. Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis. Neurology 2009 73:46-52. PMID: 19564583 [PubMed - indexed for MEDLINE] PMCID: PMC2707110 [Available on 2010/7/7]

Naismith RT, Tutlam NT, Xu J, Klawiter EC, Shepherd J, Trinkaus K, Song SK, Cross AH. Optical coherence tomography differentiates neuromyelitis optica from multiple sclerosis. Neurology 2009 72:1077-1082. PMID: 19307541 [PubMed - indexed for MEDLINE] PMCID: PMC2677471

Naismith RT, Tutlam NT, Weihl CC, Shepherd J, Cross AH. Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol 2009 66(8):1025-1027. PMID: 19667226 [PubMed - indexed for MEDLINE]

Klawiter EC, Alvarez E, Xu J, Paciorkowski A, Zhu L, Cross AH, Naismith RT. NMO IgG detected in CSF in seronegative neuromyelitis optica. Neurology 2009 72:1101-1102. PMID: 19307546 [PubMed - indexed for MEDLINE] PMCID: PMC2677472

Naismith RT, Xu J, Benzinger T, Shimony J, Shpherd J, Trinkaus K, Cross AH, Song SK. Disability in optic neuritis correlates with diffusion tensor derived directional diffusivities. Neurology 2009 72:589-594. PMID: 19073948 [PubMed - indexed for MEDLINE] PMCID: PMC2672917

Rinker JR, Trinkaus K, Naismith RT, Cross AH. Higher IgG index found in African-Americans versus Caucasians with multiple sclerosis. Neurology 2007 69:68-72. PMID: 17606883 [PubMed - indexed for MEDLINE]

Naismith RT, Trinkaus K, Cross AH. Phenotype and prognosis of African-Americans with multiple sclerosis: a retrospective chart review. Multiple Sclerosis 2006 12(6):775-81. PMID: 17263006 [PubMed - indexed for MEDLINE]

Last Updated: 1/10/2012 2:13:40 PM

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