Sanjay Jain, M.D., Ph.D.
Pathology and Immunology
Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program
8843 Wohl Clinic
development, gene expression, genomics, disease models, Gdnf-Ret signaling, kidney, bladder, innervation, stem cells, organogenesis, nervous system development, translational research
Interactions between the nervous and genitourinary systems during development, molecular basis for heterogeneity in progenitors and their lineage commitments in the GU tract, injury and regeneration using animal models, mechanisms of malformations using organoids from iPSCs
The goal of my laboratory is to decipher molecular and genetic mechanisms that confer specificity in development and diseases of the urogenital and nervous system. We are investigating mechanisms of how genetic variants cause congenital genitourinary malformations, and the role of developmentally important genes in repair and regeneration in adult acute and chronic diseases, and cancers of the GU system. Within this framework we seek to understand how different epithelia come together to connect organs, the expression pattern changes at a single cell or in selected population of cells that form the basis for maintaining the progenitor stage or their differentiation into specific lineages in normal and disease states. We heavily use genetically engineered mice, injury models, organ cultures, isolation of specific populations from normal and disease structures, and human iPSC cells as model systems. Our research program is supported by grants from NIH, March of Dimes and Washington University.
Reginensi A, Hoshi M, Boualia SK, Bouchard M, Jain S, McNeill H. Yap and Taz are Required for Ret-Dependent Urinary Tract Morphogenesis. Development, 2015. 142(15):2696-2703. PMID: 26243870
Sanjay Jain, MD, PhD, Michiel J. Noordam, PhD, Masato Hoshi, MD, PhD, Francesco L. Vallania, PhD, Donald F. Conrad, PhD. Validating single cell genomics for the study of renal development. Kidney International, 2014 Apr 23. doi: 10.1038/ki.2014.104. [Epub ahead of print] PMID: 24759149
Judith P. Golden, Joseph A. DeMaro III, Amanda Knoten, Masato Hoshi, Elizabeth Pehek, Eugene M. Johnson, Jr., Robert W. Gereau IV, and Sanjay Jain. Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. J. Neurosci. 2013. In press
Rajshekhar Chatterjee, Mary Hoffman, Paul Cliften, Surya Seshan, Helen Liapis, Sanjay Jain. Targeted candidate exome capture in conjunction with multiindexing and next-generation sequencing identifies known and novel deleterious variants in Alport’s and renal malformations. PloS1, 2013. in press
Davis TK, Hoshi M, and Jain S. Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development. Mech Dev. 2013 Mar 28. doi:pii: S0925-4773(13)00025-7. 10.1016/j.mod.2013.03.001. [Epub ahead of print] PMID:23542432. “PMCID-In Process” NIHMS 462467.
Hoshi M, Batourina E, Mendelsohn, C and Jain S. Novel regulatory mechanisms of early upper and lower urinary tract patterning by RetY1015 docking tyrosine in mice. Development 2012: Jul;139(13):2405-15. PMID: 22627285. PMCID: PMC3367447
Featured in Research Highlights by Susan J. Allison- Nature Reviews Nephrology 8, 432 (August 2012).
Chatterjee R, Ramos E, Hmiel P, Beck A, Hruska K, Coplen D, Liapis H, Mitra R, Austin P, Druley T and Jain S. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET signaling complex in a cohort of living US patients with urinary tract malformations. Human Genetics 2012: Nov;131(11):1725-38. PMID: 22729463. PMCID: PMC3551468.
Jain S, De Petris L, Hoshi M, Akilesh S, Chatterjee R, Liapis H. Expression profiles of podocytes exposed to high glucose reveal new insights into early diabetic glomerulopathy. Lab. Invest. 2011. 91:488-498. (cover illustration) (corresponding author). PMID:21102505. PMCID: PMC3068212
Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. WT1-regulated expression of Sulfs is required for GDNF bioavailability in the spermatogonial stem cell niche. Glycobiology. 2011. 21(2):152-61. PMID:20855470. PMC Journal - In Process
Rozen EJ, Schmidt H, Dolcet X, Basson M, Jain S and Encinas M. Loss of Sprouty1 rescues renal agenesis in Ret knockin mice lacking tyrosine 1062. JASN 2009; 20(2):255-259. PMCID: PMC2637045.
Jain S, Knoten A, Hoshi M, Wang H, Vohra B, Heuckeroth R, Milbrandt J. Organotypic specificity of RET-docking tyrosine residues in pathogenesis of neurocristopathies and renal malformations in mice. JCI 2010 120(3)1-14. (Corresponding Author). (Featured in Highlights of the Month).
Golden J, Hoshi M, Nassar M, Enomoto H, Wood J, Milbrandt J, Gereau R, Johnson, Jr. E and Jain S. RET Signaling is Required for Survival and Normal Function of Non-Peptidergic Nociceptors. J. Neurosci 2010. (In Press).
Jain S. The many faces of RET dysfunction in kidney. Organogenesis 2009 5(4):1-14. PMC Journal - In Process
Jain S, Suarez AA, McGuire J and Liapis H. Expression profiles of Renal Dysplasia Reveal New Insights in Renal Development and Disease. Pediatric Nephrology 2007 22(7): 962-974.
Jain S, Encinas, M, Johnson, E and Milbrandt J. Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes & Development 2006 20: 321-333. (Corresponding Author).
Last Updated: 9/19/2016 8:35:44 AM
Overview showing integrated research areas in genitourinary biology in the Jain Lab