Audrey R. Odom John, M.D., Ph.D.

Associate Professor
Pediatrics
Infectious Diseases

Molecular Microbiology and Microbial Pathogenesis Program
Plant and Microbial Biosciences Program

  • 314-747-2370

  • 314-286-2040

  • 8208

  • MPRB, 6th floor, entry #5

  • odom_a@WUSTL.EDU

  • http://research.peds.wustl.edu/labs/odom_a/

  • @odomjohnlab

  • malaria, metabolism, microbiology, parasitology, drug development, diagnostics

  • Metabolism in the malaria parasite, Plasmodium falciparum

Research Abstract:

New drugs are urgently needed to treat malaria, which causes nearly 500,000 deaths per year, mostly in very young children. We study the basic molecular and cellular biology of the malaria parasite, Plasmodium falciparum, in order to identify new ways to diagnose and treat malaria. Our primary research goals are to understand the biological functions of specific metabolic pathways in the malaria parasite--that is, to understand what the parasite needs to make, and why it needs to make it.

Our lab is part of the Pathobiology Research Unit in the Department of Pediatrics. We are located on the 6th floor of the McDonnell Pediatric Research Building.

Selected Publications:

Please see full publication list on my Google scholar page: https://scholar.google.com/citations?hl=en&user=zlaEkG4AAAAJ

Schaber CL, Katta N, Bollinger LB, Mwale M, Mlotha-Mitole R, Trehan I, Raman B, Odom John AR. Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants. J Infect Dis. 2018 Apr 23;217(10):1553-1560. doi: 10.1093/infdis/jiy072. PubMed PMID: 29415208.

Guggisberg AM, Sayler KA, Wisely SM, Odom John AR. Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer. mSphere. 2018 Apr 18;3(2). pii: e00067-18. doi: 10.1128/mSphere.00067-18. Print 2018 Apr 25. PubMed PMID: 29669881; PubMed Central PMCID: PMC5907657.

Mathews, E and Odom John, AR. Tackling resistance: emerging antimalarials and new parasite targets in the era of elimination. F1000Research, 2018, 7: 1170. PMID pending.

Guggisberg AM, Frasse PM, Jezewski, AJ, Kafai, NM, Gandhi, AY, Erlinger SJ, Odom John AR. Suppression of drug resistance reveals a genetic mechanism of metabolic plasticity in malaria parasites. BioRxiv 2018 June 18. (https://doi.org/10.1101/155523)

Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, Odom John AR. MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis. Scientific Reports, 2017 Aug 21;7(1):8400. doi: 10.1038/s41598-017-07159-y. PubMed PMID: 28827774; PubMed Central PMCID: PMC5567135.

Kafai NM, Odom John AR.Malaria in Children.Infect Dis Clin North Am. 2018 Mar;32(1):189-200. doi: 10.1016/j.idc.2017.10.008. Epub 2017 Dec 18. Review. PubMed PMID: 29269188; PubMed Central PMCID: PMC6051527.

Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW. A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format to Identify Inhibitors of Malarial and Human Glucose Transporters. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec. PubMed [citation] PMID: 27736766, PMCID: PMC5119023

Guggisberg AM, Sundararaman SA, Lanaspa M, Moraleda C, González R, Mayor A, Cisteró P, Hutchinson D, Kremsner PG, Hahn BH, Bassat Q, Odom AR. Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure with Fosmidomycin-Clindamycin. J Infect Dis. 2016 Oct 1;214(7):1085-91. doi: 10.1093/infdis/jiw304. Epub 2016 Jul 20. PubMed [citation] PMID: 27443612, PMCID: PMC5021231

Imlay LS, Armstrong CM, Masters MC, Li T, Price KE, Edwards RL, Mann KM, Li LX, Stallings CL, Berry NG, O`Neill PM, Odom AR. Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target. ACS Infect Dis. 2015 Apr 10;1(4):157-167. Epub 2015 Mar 2. PubMed [citation] PMID: 26783558, PMCID: PMC4714788

Kelly M, Su CY, Schaber C, Crowley JR, Hsu FF, Carlson JR, Odom AR. Malaria parasites produce volatile mosquito attractants. mBio. 2015 Mar 24;6(2). pii: e00235-15. doi: 10.1128/mBio.00235-15. PubMed [citation] PMID: 25805727, PMCID: PMC4453533

Guggisberg AM, Park J, Edwards RL, Kelly ML, Hodge DM, Tolia NH*, Odom AR*. A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun. 2014 Jul 24;5:4467. doi: 10.1038/ncomms5467. PubMed [citation] PMID: 25058848, PMCID: PMC4112465

Last Updated: 8/8/2018 10:21:12 AM

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