Audrey R. Odom John, M.D., Ph.D.
Molecular Microbiology and Microbial Pathogenesis Program
Plant and Microbial Biosciences Program
MPRB, 6th floor, entry #5
drug and target discovery, malaria, metabolism, Microbiology, parasitology
Isoprenoid metabolism in the malaria parasite, Plasmodium falciparum
New drugs are urgently needed to treat malaria, which causes nearly one million deaths per year, mostly very young children. We study the basic molecular and cellular biology of the malaria parasite, Plasmodium falciparum, in order to identify new antimalarial drug targets. Our primary research goals are to understand the biological functions of specific metabolic pathways in the malaria parasite--that is, to understand what the parasite needs to make, and why it needs to make it.
Our lab is part of the Pathobiology Research Unit in the Department of Pediatrics. We are located on the 6th floor of the McDonnell Pediatric Research Building.
Odom AR. Five questions about non-mevalonate isoprenoid biosynthesis. PLoS Pathog. 2011 7(12):e1002323. PMCID: 3245312.
Hale I, O`Neill P, Berry N, Odom AR, Sharma R. The MEP pathway and its inhibitors as potential new drug targets. MedChemComm. 2012 (3):418-33.
Zhang B, Watts KM, Hodge D, Kemp LM, Hunstad DA, Hicks LM, and Odom AR. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. Biochemistry. 2011 50(17): 3570-7.
Odom AR, Van Voorhis WC. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Mol Biochem Parasitol 2010 Apr; 170(2):108-11. PMCID: 2814890.
Odom AR, Stahlberg A, Wente SR, York JD. A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science 2000 287(5460): 2026-9.
York JD, Odom AR, Murphy R, Ives EB, Wente SR. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science. 1999 285(5424): 96-100.
Last Updated: 3/22/2017 2:20:55 PM