Todd Druley, M.D., Ph.D.

Associate Professor
Pediatrics
Hematology/Oncology
Genetics
Developmental Biology

Molecular Genetics and Genomics Program
Developmental, Regenerative and Stem Cell Biology Program
Human and Statistical Genetics Program

Research Abstract:

The Druley lab is focused on the hypothesis that many pediatric cancers arise from defects during normal tissue differentiation and development. To better understand those mechanisms, we are developing and applying novel genomic, epigenomic and computational methods to better understand pathologic and physiologic implications of clonal hematopoiesis for risk stratification, modeling of interplay between germline and somatic mutation and improving therapeutic selection in pediatric leukemias. Our work involves patient-specific human iPS modeling, hESC modeling, collaboration in multiple international projects on complex pediatric and adult phenotypes using high-throughput sequencing and computational strategies for improved mechanistic understanding.

Selected Publications:

As of 8/2018; 43 publications, h-index = 19, 2435 citations:

Wong-Siegel JR, Johnson KJ, Gettinger K, Cousins N, McAmis N, Zamarione A, Druley TE. Congenital neurodevelopmental anomalies in pediatric and young adult cancer. Am J Med Genet A. 2017. PMID:28851129

Young, A.L., Challen, G.A., Birmann, B.M., Druley, T.E. (2016) Clonal hematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. Nat Commun. 2016 Aug 22;7:12484. doi: 10.1038/ncomms12484.

Druley, T.E. (2016) The relative contributions of germline variation, epimutation and somatic mutation to paediatric leukemia predisposition. EMJ Hematol, 4(1), 110-116. http://emjreviews.com/therapeutic-area/hematology/the-relative-contributions-of-germline-variation-epimutation-and-somatic-mutation-to-paediatric-leukaemia-predisposition/

Young, A.L., Wong, T.N., Hughes, A.E.O., Heath, S.E., Ley, T.J., Link, D.C., Druley, T.E. (2015) Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing. Leukemia, 2015 Feb 3. doi: 10.1038/leu.2015.17. PMID: 25644247

Wong, T.N.*, Ramsingh, G.*, Young, A.L.*, Miller, C.A., Touma, W., Welch, J.S., Lamprecht, T., Shen, D., Hundal, J., Fulton, R.S., Heath, S., Baty, J.D., Ding, L., Mardis, E.R., Westervelt, P., DiPersio, J.F., Walter, M.J., Graubert, T.A., Ley, T.J., Druley, T.E., Link, D.C., Wilson, R.K. The role of early TP53 mutations in the evolution of therapy-related AML. Nature, 2015 Feb 26;518(7540):552-5. PMID: 25487151

Valentine, M.C., Linabery, A.M., Chasnoff, S., Hughes, A.E., Mallaney, C., Sanchez, N., Giacalone, J., Heerema, N.A., Hilden, J.M., Spector, L.G., Ross, J.A.*, Druley, T.E.* (2014) Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children’s Oncology Group report. Leukemia. doi: 10.1038/leu.2013.367. PubMed: 24301523.

Druley TE, Vallania FML, Varley KE, Knowles OL, Bonds JA, Doniger SW, Wegner DJ, Hamvas A, Cole FS, Fay JC and Mitra RD. (2009) Quantification of rare allelic variants from pooled genomic DNA. Nature Methods Apr; 6: 263-265. PMCID: PMC2776647

Last Updated: 8/15/2018 9:22:32 AM

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