Michael R. Bruchas, Ph.D.
Molecular Cell Biology Program
behavior, G protein coupled receptors, neurobiology, pain, optogenetics, in vivo physiology, in vivo calcium imaging, psychiatry, depression, addiction, anxiety, signal transduction in vitro and in vivo, pharmacology
Neuromodulation and GPCR signaling in neural circuits of affective behavior
Stress can dramatically alter motivated behavior, leading to maladaptive decision-making, depression, anxiety, and addiction. The stress response is controlled by G-protein coupled (GPCR) neuromodulator receptors in the central and peripheral nervous system. A vast number of pharmaceutical agents directly target GPCRs. We are interested in discovering how GPCR receptor systems function in the context of stress-induced affective behaviors including anxiety, depression, pain, and addiction. We adopt a multidisciplinary, cutting-edge approaches including optogenetics and in vivo imaging to study the pharmacological, biochemical, physiological, and neurobiological basis of stress and affective behaviors.
R. Al-Hasani, J.G. McCall, G. Shin, G.P. Schmitz, J.M. Bernardi, C.-O Pyo, S. Park, N.A., Marcinkiewcz C.M., Crowley, M.J. Krashes, B.B. Lowell, T.L. Kash, J.A. Rogers and M.R. Bruchas (2015) Distinct subpopulations of nucleus accumbens dynorphin neurons drive aversion or reward. Neuron, in press.
J.W. Jeong*, J.G. McCall*(co-first author), G. Shin, Y. Zhang, R. Al-Hasani, M. Kim, S. Li, J.Y. Sim, D.Y. Hong, Y. Shi, G. P. Schmitz, L. Xia, Z. He, P. Gamble, Z. Ray, Y. Huang, M.R. Bruchas*, J.A. Rogers*. Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics. (2015) Cell. 162:662-74
CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety. (2015) Neuron, 87(3):605-20.
E.R. Siuda, M. Schmidt, B. Copits, M. Baird., R. Al-Hasani, J. McCall, W. Planer, R. Gereau, M.R.Bruchas. Spatiotemporal control of opioid signaling and behavior. (2015) Neuron, 86(4):923-35.
T.-I. Kim*, J.G. McCall*, Y.H. Jung, X. Huang, E.R. Siuda, Y. Li, J. Song, Y.M. Song, H.A. Pao, R.-H Kim, C. Lu, S.D. Lee, I.S. Song, G.C. Shin, R. Al-Hasani, S. Kim, M.P. Tan, Y. Huang, F. Omenetto, J.A. Rogers and M.R. Bruchas (2013)
Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics. Science, 340:211-216.
Zhang NR, Planer W, Siuda ER, Zhao HC, Stickler L, Baird MA, Cao YQ and Bruchas MR (2012). Serine
363 is Required for NOPR Desensitization, Internalization, and Arrestin Signaling. J. Biol. Chem. 50:42019-42030.
Last Updated: 8/25/2015 9:12:59 AM